Extracellular vesicle RNA in liver disease

Tushar C Patel, Hiroaki Haga

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Extracellular vesicle RNA has emerged as a mediator of intercellular communication. Hepatic epithelia, and many other cell types, can release extracellular RNA within membrane-derived vesicles such as exosomes and microvesicles, or as complexes with lipoproteins or proteins. In addition to RNA, extracellular vesicles contain proteins, lipids, and other nucleic acids. Extracellular vesicles can be taken up by other cells within the local microenvironment or at distant sites, and the transfer of their contents can modulate biological processes in recipient cells. Cell-to-cell signaling involving extracellular vesicle RNA can contribute to normal tissue homeostasis, as well as participating in pathophysiological processes involved in diverse hepatic diseases such as liver cancers, injury from drugs, viruses or alcohol, viral infection, fatty liver disease, and biliary tract disease. In addition, extracellular vesicle RNA may have potential value as a biomarker for disease.

Original languageEnglish (US)
Title of host publicationSignaling Pathways in Liver Diseases: Third Edition
PublisherWiley Blackwell
Pages130-138
Number of pages9
ISBN (Print)9781118663387, 9781118663394
DOIs
StatePublished - Sep 28 2015

Keywords

  • Biomarkers
  • Exosomes
  • Extracellular vesicles
  • Fatty liver
  • Hepatocellular cancer
  • MicroRNA
  • Microvesicles
  • Noncoding RNA
  • Signaling
  • Tissue injury

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Patel, T. C., & Haga, H. (2015). Extracellular vesicle RNA in liver disease. In Signaling Pathways in Liver Diseases: Third Edition (pp. 130-138). Wiley Blackwell. https://doi.org/10.1002/9781118663387.ch9