Extracellular vesicle long noncoding RNA as potential biomarkers of liver cancer

Swathi Mohankumar, Tushar C Patel

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Analysis of extracellular vesicles (EV) and their contents may be useful as disease biomarkers if they reflect the contents of cells of origin, differ between normal and diseased tissue and can be reliably detected. An increasing number of long noncoding RNA (lncRNA) are being reported to be aberrantly expressed in human cancers. These tumor-associated lncRNA may have potential as new biomarkers of disease. In this review, we highlight lncRNAs that are commonly associated with hepatocellular cancer, and summarize their potential biological roles and underlying molecular mechanisms. While lncRNA can be detected in the circulation, their low expression within circulating vesicles will require the use of highly sensitive detection technologies such as digital polymerase chain reaction or next-generation sequencing. While the integrity and functional role of tumor-specific lncRNAs within EV have yet to be established, their presence or enrichment within tumor cell-derived EV offers promise for their potential as disease biomarkers.

Original languageEnglish (US)
Pages (from-to)249-256
Number of pages8
JournalBriefings in Functional Genomics
Volume15
Issue number3
DOIs
StatePublished - 2016

Fingerprint

Long Noncoding RNA
Biomarkers
Liver Neoplasms
Liver
Tumors
Neoplasms
Polymerase chain reaction
Cells
Extracellular Vesicles
Tissue
Technology
Polymerase Chain Reaction

Keywords

  • Cancer diagnosis
  • Digital PCR
  • Exosomes
  • Extracellular vesicles
  • Hepatocellular cancer
  • RNA genes

ASJC Scopus subject areas

  • Biochemistry
  • Genetics
  • Molecular Biology

Cite this

Extracellular vesicle long noncoding RNA as potential biomarkers of liver cancer. / Mohankumar, Swathi; Patel, Tushar C.

In: Briefings in Functional Genomics, Vol. 15, No. 3, 2016, p. 249-256.

Research output: Contribution to journalArticle

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