Extra-peritoneal laparoscopic para-aortic lymphadenectomy - A prospective cohort study of 293 patients with endometrial cancer

Sean Christopher Dowdy, Giovanni Aletti, William Arthur Cliby, Karl C. Podratz, Andrea Mariani

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Objective: To determine if extra-peritoneal laparoscopic para-aortic (PA) lymphadenectomy allows a reliable assessment of PA nodes in patients with endometrial cancer (EC). Methods: In October of 2005, a single surgeon began performing extra-peritoneal laparoscopic PA lymphadenectomy for patients with EC. A prospective cohort study was initiated from October 2005 through October 2007. Staging of Group A included extra-peritoneal laparoscopic PA lymphadenectomy, while Group B underwent staging via laparotomy. Results: In a 24 month period, 293 patients underwent surgical treatment for EC, 203 of them underwent complete staging as determined by previously published criteria. Extra-peritoneal laparoscopic PA lymphadenectomy to the renal veins was successful in 35/38 patients (92%). Mean BMI was 33.0 for Group A and 32.3 for Group B (p = NS). Mean EBL and hospital stay were lower in Group A compared to Group B (163 vs 373 cm3, p < 0.0001; median 2 vs 4 nights, p < 0.001). The total number of PA nodes harvested was not statistically different between Groups A and B (16.5 vs 19.6). Interestingly, in Group A the total number of PA nodes was greater for patients with BMI > 35, (21.6 vs 13.1), while in Group B fewer nodes were removed in obese patients (17.8 vs 20.5). Conclusions: Extra-peritoneal laparoscopy is a reliable method to routinely reach the level of the renal veins, even in obese patients. This approach was feasible in over 90% of unselected patients and well-tolerated.

Original languageEnglish (US)
Pages (from-to)418-424
Number of pages7
JournalGynecologic Oncology
Volume111
Issue number3
DOIs
StatePublished - Dec 2008

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Endometrial Neoplasms
Lymph Node Excision
Cohort Studies
Prospective Studies
Renal Veins
Laparoscopy
Laparotomy
Length of Stay

Keywords

  • Endometrial carcinoma
  • Laparoscopy
  • Lymphadenectomy

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Oncology

Cite this

Extra-peritoneal laparoscopic para-aortic lymphadenectomy - A prospective cohort study of 293 patients with endometrial cancer. / Dowdy, Sean Christopher; Aletti, Giovanni; Cliby, William Arthur; Podratz, Karl C.; Mariani, Andrea.

In: Gynecologic Oncology, Vol. 111, No. 3, 12.2008, p. 418-424.

Research output: Contribution to journalArticle

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