External loads associated with anterior cruciate ligament injuries increase the correlation between tibial slope and ligament strain during in vitro simulations of in vivo landings

Nathaniel A. Bates, Maria C. Mejia Jaramillo, Manuela Vargas, April L. McPherson, Nathan Schilaty, Christopher V. Nagelli, Aaron Krych, Timothy Hewett

Research output: Contribution to journalArticle

Abstract

Background: The aim of the present study was to evaluate the relationship between tibial slope angle and ligament strain during in vitro landing simulations that induce ACL failure through the application of variable external loading at the knee. The hypothesis tested was that steeper posterior tibial slope angle would be associated with higher ACL strain during a simulated landing task across all external loading conditions. Methods: Kinetics previously derived from an in vivo cohort performing drop landings were reproduced on 45 cadaveric knees via the mechanical impact simulator. MRIs were taken of each specimen and used to calculate medial compartment posterior tibial slope, lateral compartment posterior tibial slope, and coronal plane tibial slope. Linear regression analyses were performed between these angles and ACL strain to determine whether tibial slope was a predictive factor for ACL strain. Findings: Medial and lateral posterior tibial slope were predictive factors for ACL strain during some landings with higher combined loads. Medial posterior slope was more predictive of ACL strain in most landings for male specimens, while lateral posterior and coronal slope were more predictive in female specimens, but primarily when high abduction moments were applied. Interpretation: Tibial slope has the potential to influence ACL strain during landing, especially when large abduction moments are present at the knee. Deleterious external loads to the ACL increase the correlation between tibial slope and ACL strain, which indicates that tibial slope angles are an additive factor for athletes apt to generate large out-of-plane knee moments during landing tasks.

Original languageEnglish (US)
Pages (from-to)84-94
Number of pages11
JournalClinical Biomechanics
Volume61
DOIs
StatePublished - Jan 1 2019

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Ligaments
Knee
Athletes
Linear Models
Regression Analysis
In Vitro Techniques
Anterior Cruciate Ligament Injuries

Keywords

  • Anterior cruciate ligament
  • Injury risk factors
  • Knee biomechanics
  • Landing
  • Tibial slope

ASJC Scopus subject areas

  • Biophysics
  • Orthopedics and Sports Medicine

Cite this

External loads associated with anterior cruciate ligament injuries increase the correlation between tibial slope and ligament strain during in vitro simulations of in vivo landings. / Bates, Nathaniel A.; Mejia Jaramillo, Maria C.; Vargas, Manuela; McPherson, April L.; Schilaty, Nathan; Nagelli, Christopher V.; Krych, Aaron; Hewett, Timothy.

In: Clinical Biomechanics, Vol. 61, 01.01.2019, p. 84-94.

Research output: Contribution to journalArticle

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AU - Vargas, Manuela

AU - McPherson, April L.

AU - Schilaty, Nathan

AU - Nagelli, Christopher V.

AU - Krych, Aaron

AU - Hewett, Timothy

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