External-beam radiation therapy in the treatment of diffuse tracheobronchial amyloidosis

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35 Scopus citations

Abstract

Tracheobronchial amyloidosis is characterized by deposits of amyloid in airway walls. No effective treatment is known. We describe a 59-year-old woman who presented with increasing symptoms of airway obstruction due to diffuse deposition of amyloid throughout her tracheobronchial tree. She was treated with external-beam radiation therapy (20 Gy) with marked improvement in her symptoms, effort tolerance, bronchoscopic appearance, and forced expiratory volume in 1 second (1.39 L to 1.97 L [42%]). This improvement was maintained during 21 months of follow-up.

Original languageEnglish (US)
Article number63233
Pages (from-to)853-856
Number of pages4
JournalMayo Clinic proceedings
Volume76
Issue number8
DOIs
StatePublished - Jan 1 2001

ASJC Scopus subject areas

  • Medicine(all)

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