Extent, location, and clinical significance of non-infarct-related coronary artery disease among patients with ST-elevation myocardial infarction

Duk Woo Park, Robert M. Clare, Phillip Schulte, Karen S. Pieper, Linda K. Shaw, Robert M. Califf, E. Magnus Ohman, Frans Van De Werf, Sameer Hirji, Robert A. Harrington, Paul W. Armstrong, Christopher B. Granger, Myung Ho Jeong, Manesh R. Patel

Research output: Contribution to journalArticle

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Abstract

IMPORTANCE Little information exists about the anatomical characteristics and clinical relevance of non-infarct-related artery (IRA) disease among patients with ST-segment elevationmyocardial infarction (STEMI). OBJECTIVES To investigate the incidence, extent, and location of obstructive non-IRA disease and compare 30-day mortality according to the presence of non-IRA disease in patients with STEMI. DESIGN, SETTING, AND PARTICIPANTS Retrospective study of patients pooled from a convenience sample of 8 independent, international, randomized STEMI clinical trials published between 1993 and 2007. Follow-up varied from 1 month to 1 year. Among 68 765 patients enrolled in the trials, 28 282 patients with valid angiographic information were included in this analysis. Obstructive coronary artery disease was defined as stenosis of 50% or more of the diameter of a major epicardial artery. To assess the generalizability of trial-based results, external validation was performed using observational data for patients with STEMI from the Korea Acute Myocardial Infarction Registry (KAMIR) (between November 1, 2005, and December 31, 2013; n = 18 217) and the Duke Cardiovascular Databank (between January 1, 2005, and December 31, 2012; n = 1812). MAIN OUTCOMES AND MEASURES Thirty-day mortality following STEMI. RESULTS Overall, 52.8%(14 929 patients) had obstructive non-IRA disease; 29.6%involved 1 vessel and 18.8% involved 2 vessels. There was no substantial difference in the extent and distribution of non-IRA disease according to the IRA territory. Unadjusted and adjusted rates of 30-day mortality were significantly higher in patients with non-IRA disease than in those without non-IRA disease (unadjusted, 4.3%vs 1.7%, respectively; risk difference, 2.7%[95% CI, 2.3%to 3.0%], P <.001; and adjusted, 3.3%vs 1.9%, respectively; risk difference, 1.4% [95%CI, 1.0% to 1.8%], P <.001). The overall prevalence and association of non-IRA disease with 30-day mortality was consistent with findings from the KAMIR registry (adjusted, 3.6% for patients with non-IRA disease vs 2.5%in those without it; risk difference, 1.1%[95%CI, 0.6%to 1.7%]; P <.001), but not with the Duke database (adjusted, 4.7%with non-IRA disease vs 4.3%without it; risk difference, 0.4%[95%CI,-1.4%to 2.2%], P =.65). CONCLUSIONS AND RELEVANCE In a retrospective pooled analysis of 8 clinical trials, obstructive non-IRA disease was common among patients presenting with STEMI, and was associated with a modest statistically significant increase in 30-day mortality. These findings require confirmation in prospectively designed studies, but raise questions about the appropriateness and timing of non-IRA revascularization in patients with STEMI.

Original languageEnglish (US)
Pages (from-to)2019-2027
Number of pages9
JournalJAMA - Journal of the American Medical Association
Volume312
Issue number19
DOIs
StatePublished - Nov 19 2014
Externally publishedYes

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Coronary Artery Disease
Arteries
Infarction
Mortality
Registries
Korea
ST Elevation Myocardial Infarction
Myocardial Infarction
Clinical Trials
Databases
Pathologic Constriction
Retrospective Studies
Outcome Assessment (Health Care)

ASJC Scopus subject areas

  • Medicine(all)

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Extent, location, and clinical significance of non-infarct-related coronary artery disease among patients with ST-elevation myocardial infarction. / Park, Duk Woo; Clare, Robert M.; Schulte, Phillip; Pieper, Karen S.; Shaw, Linda K.; Califf, Robert M.; Magnus Ohman, E.; Van De Werf, Frans; Hirji, Sameer; Harrington, Robert A.; Armstrong, Paul W.; Granger, Christopher B.; Jeong, Myung Ho; Patel, Manesh R.

In: JAMA - Journal of the American Medical Association, Vol. 312, No. 19, 19.11.2014, p. 2019-2027.

Research output: Contribution to journalArticle

Park, DW, Clare, RM, Schulte, P, Pieper, KS, Shaw, LK, Califf, RM, Magnus Ohman, E, Van De Werf, F, Hirji, S, Harrington, RA, Armstrong, PW, Granger, CB, Jeong, MH & Patel, MR 2014, 'Extent, location, and clinical significance of non-infarct-related coronary artery disease among patients with ST-elevation myocardial infarction', JAMA - Journal of the American Medical Association, vol. 312, no. 19, pp. 2019-2027. https://doi.org/10.1001/jama.2014.15095
Park, Duk Woo ; Clare, Robert M. ; Schulte, Phillip ; Pieper, Karen S. ; Shaw, Linda K. ; Califf, Robert M. ; Magnus Ohman, E. ; Van De Werf, Frans ; Hirji, Sameer ; Harrington, Robert A. ; Armstrong, Paul W. ; Granger, Christopher B. ; Jeong, Myung Ho ; Patel, Manesh R. / Extent, location, and clinical significance of non-infarct-related coronary artery disease among patients with ST-elevation myocardial infarction. In: JAMA - Journal of the American Medical Association. 2014 ; Vol. 312, No. 19. pp. 2019-2027.
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abstract = "IMPORTANCE Little information exists about the anatomical characteristics and clinical relevance of non-infarct-related artery (IRA) disease among patients with ST-segment elevationmyocardial infarction (STEMI). OBJECTIVES To investigate the incidence, extent, and location of obstructive non-IRA disease and compare 30-day mortality according to the presence of non-IRA disease in patients with STEMI. DESIGN, SETTING, AND PARTICIPANTS Retrospective study of patients pooled from a convenience sample of 8 independent, international, randomized STEMI clinical trials published between 1993 and 2007. Follow-up varied from 1 month to 1 year. Among 68 765 patients enrolled in the trials, 28 282 patients with valid angiographic information were included in this analysis. Obstructive coronary artery disease was defined as stenosis of 50{\%} or more of the diameter of a major epicardial artery. To assess the generalizability of trial-based results, external validation was performed using observational data for patients with STEMI from the Korea Acute Myocardial Infarction Registry (KAMIR) (between November 1, 2005, and December 31, 2013; n = 18 217) and the Duke Cardiovascular Databank (between January 1, 2005, and December 31, 2012; n = 1812). MAIN OUTCOMES AND MEASURES Thirty-day mortality following STEMI. RESULTS Overall, 52.8{\%}(14 929 patients) had obstructive non-IRA disease; 29.6{\%}involved 1 vessel and 18.8{\%} involved 2 vessels. There was no substantial difference in the extent and distribution of non-IRA disease according to the IRA territory. Unadjusted and adjusted rates of 30-day mortality were significantly higher in patients with non-IRA disease than in those without non-IRA disease (unadjusted, 4.3{\%}vs 1.7{\%}, respectively; risk difference, 2.7{\%}[95{\%} CI, 2.3{\%}to 3.0{\%}], P <.001; and adjusted, 3.3{\%}vs 1.9{\%}, respectively; risk difference, 1.4{\%} [95{\%}CI, 1.0{\%} to 1.8{\%}], P <.001). The overall prevalence and association of non-IRA disease with 30-day mortality was consistent with findings from the KAMIR registry (adjusted, 3.6{\%} for patients with non-IRA disease vs 2.5{\%}in those without it; risk difference, 1.1{\%}[95{\%}CI, 0.6{\%}to 1.7{\%}]; P <.001), but not with the Duke database (adjusted, 4.7{\%}with non-IRA disease vs 4.3{\%}without it; risk difference, 0.4{\%}[95{\%}CI,-1.4{\%}to 2.2{\%}], P =.65). CONCLUSIONS AND RELEVANCE In a retrospective pooled analysis of 8 clinical trials, obstructive non-IRA disease was common among patients presenting with STEMI, and was associated with a modest statistically significant increase in 30-day mortality. These findings require confirmation in prospectively designed studies, but raise questions about the appropriateness and timing of non-IRA revascularization in patients with STEMI.",
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TY - JOUR

T1 - Extent, location, and clinical significance of non-infarct-related coronary artery disease among patients with ST-elevation myocardial infarction

AU - Park, Duk Woo

AU - Clare, Robert M.

AU - Schulte, Phillip

AU - Pieper, Karen S.

AU - Shaw, Linda K.

AU - Califf, Robert M.

AU - Magnus Ohman, E.

AU - Van De Werf, Frans

AU - Hirji, Sameer

AU - Harrington, Robert A.

AU - Armstrong, Paul W.

AU - Granger, Christopher B.

AU - Jeong, Myung Ho

AU - Patel, Manesh R.

PY - 2014/11/19

Y1 - 2014/11/19

N2 - IMPORTANCE Little information exists about the anatomical characteristics and clinical relevance of non-infarct-related artery (IRA) disease among patients with ST-segment elevationmyocardial infarction (STEMI). OBJECTIVES To investigate the incidence, extent, and location of obstructive non-IRA disease and compare 30-day mortality according to the presence of non-IRA disease in patients with STEMI. DESIGN, SETTING, AND PARTICIPANTS Retrospective study of patients pooled from a convenience sample of 8 independent, international, randomized STEMI clinical trials published between 1993 and 2007. Follow-up varied from 1 month to 1 year. Among 68 765 patients enrolled in the trials, 28 282 patients with valid angiographic information were included in this analysis. Obstructive coronary artery disease was defined as stenosis of 50% or more of the diameter of a major epicardial artery. To assess the generalizability of trial-based results, external validation was performed using observational data for patients with STEMI from the Korea Acute Myocardial Infarction Registry (KAMIR) (between November 1, 2005, and December 31, 2013; n = 18 217) and the Duke Cardiovascular Databank (between January 1, 2005, and December 31, 2012; n = 1812). MAIN OUTCOMES AND MEASURES Thirty-day mortality following STEMI. RESULTS Overall, 52.8%(14 929 patients) had obstructive non-IRA disease; 29.6%involved 1 vessel and 18.8% involved 2 vessels. There was no substantial difference in the extent and distribution of non-IRA disease according to the IRA territory. Unadjusted and adjusted rates of 30-day mortality were significantly higher in patients with non-IRA disease than in those without non-IRA disease (unadjusted, 4.3%vs 1.7%, respectively; risk difference, 2.7%[95% CI, 2.3%to 3.0%], P <.001; and adjusted, 3.3%vs 1.9%, respectively; risk difference, 1.4% [95%CI, 1.0% to 1.8%], P <.001). The overall prevalence and association of non-IRA disease with 30-day mortality was consistent with findings from the KAMIR registry (adjusted, 3.6% for patients with non-IRA disease vs 2.5%in those without it; risk difference, 1.1%[95%CI, 0.6%to 1.7%]; P <.001), but not with the Duke database (adjusted, 4.7%with non-IRA disease vs 4.3%without it; risk difference, 0.4%[95%CI,-1.4%to 2.2%], P =.65). CONCLUSIONS AND RELEVANCE In a retrospective pooled analysis of 8 clinical trials, obstructive non-IRA disease was common among patients presenting with STEMI, and was associated with a modest statistically significant increase in 30-day mortality. These findings require confirmation in prospectively designed studies, but raise questions about the appropriateness and timing of non-IRA revascularization in patients with STEMI.

AB - IMPORTANCE Little information exists about the anatomical characteristics and clinical relevance of non-infarct-related artery (IRA) disease among patients with ST-segment elevationmyocardial infarction (STEMI). OBJECTIVES To investigate the incidence, extent, and location of obstructive non-IRA disease and compare 30-day mortality according to the presence of non-IRA disease in patients with STEMI. DESIGN, SETTING, AND PARTICIPANTS Retrospective study of patients pooled from a convenience sample of 8 independent, international, randomized STEMI clinical trials published between 1993 and 2007. Follow-up varied from 1 month to 1 year. Among 68 765 patients enrolled in the trials, 28 282 patients with valid angiographic information were included in this analysis. Obstructive coronary artery disease was defined as stenosis of 50% or more of the diameter of a major epicardial artery. To assess the generalizability of trial-based results, external validation was performed using observational data for patients with STEMI from the Korea Acute Myocardial Infarction Registry (KAMIR) (between November 1, 2005, and December 31, 2013; n = 18 217) and the Duke Cardiovascular Databank (between January 1, 2005, and December 31, 2012; n = 1812). MAIN OUTCOMES AND MEASURES Thirty-day mortality following STEMI. RESULTS Overall, 52.8%(14 929 patients) had obstructive non-IRA disease; 29.6%involved 1 vessel and 18.8% involved 2 vessels. There was no substantial difference in the extent and distribution of non-IRA disease according to the IRA territory. Unadjusted and adjusted rates of 30-day mortality were significantly higher in patients with non-IRA disease than in those without non-IRA disease (unadjusted, 4.3%vs 1.7%, respectively; risk difference, 2.7%[95% CI, 2.3%to 3.0%], P <.001; and adjusted, 3.3%vs 1.9%, respectively; risk difference, 1.4% [95%CI, 1.0% to 1.8%], P <.001). The overall prevalence and association of non-IRA disease with 30-day mortality was consistent with findings from the KAMIR registry (adjusted, 3.6% for patients with non-IRA disease vs 2.5%in those without it; risk difference, 1.1%[95%CI, 0.6%to 1.7%]; P <.001), but not with the Duke database (adjusted, 4.7%with non-IRA disease vs 4.3%without it; risk difference, 0.4%[95%CI,-1.4%to 2.2%], P =.65). CONCLUSIONS AND RELEVANCE In a retrospective pooled analysis of 8 clinical trials, obstructive non-IRA disease was common among patients presenting with STEMI, and was associated with a modest statistically significant increase in 30-day mortality. These findings require confirmation in prospectively designed studies, but raise questions about the appropriateness and timing of non-IRA revascularization in patients with STEMI.

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