TY - JOUR
T1 - Extent, location, and clinical significance of non-infarct-related coronary artery disease among patients with ST-elevation myocardial infarction
AU - Park, Duk Woo
AU - Clare, Robert M.
AU - Schulte, Phillip J.
AU - Pieper, Karen S.
AU - Shaw, Linda K.
AU - Califf, Robert M.
AU - Magnus Ohman, E.
AU - Van De Werf, Frans
AU - Hirji, Sameer
AU - Harrington, Robert A.
AU - Armstrong, Paul W.
AU - Granger, Christopher B.
AU - Jeong, Myung Ho
AU - Patel, Manesh R.
N1 - Publisher Copyright:
© 2014 American Medical Association. All rights reserved.
PY - 2014/11/19
Y1 - 2014/11/19
N2 - IMPORTANCE Little information exists about the anatomical characteristics and clinical relevance of non-infarct-related artery (IRA) disease among patients with ST-segment elevationmyocardial infarction (STEMI). OBJECTIVES To investigate the incidence, extent, and location of obstructive non-IRA disease and compare 30-day mortality according to the presence of non-IRA disease in patients with STEMI. DESIGN, SETTING, AND PARTICIPANTS Retrospective study of patients pooled from a convenience sample of 8 independent, international, randomized STEMI clinical trials published between 1993 and 2007. Follow-up varied from 1 month to 1 year. Among 68 765 patients enrolled in the trials, 28 282 patients with valid angiographic information were included in this analysis. Obstructive coronary artery disease was defined as stenosis of 50% or more of the diameter of a major epicardial artery. To assess the generalizability of trial-based results, external validation was performed using observational data for patients with STEMI from the Korea Acute Myocardial Infarction Registry (KAMIR) (between November 1, 2005, and December 31, 2013; n = 18 217) and the Duke Cardiovascular Databank (between January 1, 2005, and December 31, 2012; n = 1812). MAIN OUTCOMES AND MEASURES Thirty-day mortality following STEMI. RESULTS Overall, 52.8%(14 929 patients) had obstructive non-IRA disease; 29.6%involved 1 vessel and 18.8% involved 2 vessels. There was no substantial difference in the extent and distribution of non-IRA disease according to the IRA territory. Unadjusted and adjusted rates of 30-day mortality were significantly higher in patients with non-IRA disease than in those without non-IRA disease (unadjusted, 4.3%vs 1.7%, respectively; risk difference, 2.7%[95% CI, 2.3%to 3.0%], P <.001; and adjusted, 3.3%vs 1.9%, respectively; risk difference, 1.4% [95%CI, 1.0% to 1.8%], P <.001). The overall prevalence and association of non-IRA disease with 30-day mortality was consistent with findings from the KAMIR registry (adjusted, 3.6% for patients with non-IRA disease vs 2.5%in those without it; risk difference, 1.1%[95%CI, 0.6%to 1.7%]; P <.001), but not with the Duke database (adjusted, 4.7%with non-IRA disease vs 4.3%without it; risk difference, 0.4%[95%CI,-1.4%to 2.2%], P =.65). CONCLUSIONS AND RELEVANCE In a retrospective pooled analysis of 8 clinical trials, obstructive non-IRA disease was common among patients presenting with STEMI, and was associated with a modest statistically significant increase in 30-day mortality. These findings require confirmation in prospectively designed studies, but raise questions about the appropriateness and timing of non-IRA revascularization in patients with STEMI.
AB - IMPORTANCE Little information exists about the anatomical characteristics and clinical relevance of non-infarct-related artery (IRA) disease among patients with ST-segment elevationmyocardial infarction (STEMI). OBJECTIVES To investigate the incidence, extent, and location of obstructive non-IRA disease and compare 30-day mortality according to the presence of non-IRA disease in patients with STEMI. DESIGN, SETTING, AND PARTICIPANTS Retrospective study of patients pooled from a convenience sample of 8 independent, international, randomized STEMI clinical trials published between 1993 and 2007. Follow-up varied from 1 month to 1 year. Among 68 765 patients enrolled in the trials, 28 282 patients with valid angiographic information were included in this analysis. Obstructive coronary artery disease was defined as stenosis of 50% or more of the diameter of a major epicardial artery. To assess the generalizability of trial-based results, external validation was performed using observational data for patients with STEMI from the Korea Acute Myocardial Infarction Registry (KAMIR) (between November 1, 2005, and December 31, 2013; n = 18 217) and the Duke Cardiovascular Databank (between January 1, 2005, and December 31, 2012; n = 1812). MAIN OUTCOMES AND MEASURES Thirty-day mortality following STEMI. RESULTS Overall, 52.8%(14 929 patients) had obstructive non-IRA disease; 29.6%involved 1 vessel and 18.8% involved 2 vessels. There was no substantial difference in the extent and distribution of non-IRA disease according to the IRA territory. Unadjusted and adjusted rates of 30-day mortality were significantly higher in patients with non-IRA disease than in those without non-IRA disease (unadjusted, 4.3%vs 1.7%, respectively; risk difference, 2.7%[95% CI, 2.3%to 3.0%], P <.001; and adjusted, 3.3%vs 1.9%, respectively; risk difference, 1.4% [95%CI, 1.0% to 1.8%], P <.001). The overall prevalence and association of non-IRA disease with 30-day mortality was consistent with findings from the KAMIR registry (adjusted, 3.6% for patients with non-IRA disease vs 2.5%in those without it; risk difference, 1.1%[95%CI, 0.6%to 1.7%]; P <.001), but not with the Duke database (adjusted, 4.7%with non-IRA disease vs 4.3%without it; risk difference, 0.4%[95%CI,-1.4%to 2.2%], P =.65). CONCLUSIONS AND RELEVANCE In a retrospective pooled analysis of 8 clinical trials, obstructive non-IRA disease was common among patients presenting with STEMI, and was associated with a modest statistically significant increase in 30-day mortality. These findings require confirmation in prospectively designed studies, but raise questions about the appropriateness and timing of non-IRA revascularization in patients with STEMI.
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U2 - 10.1001/jama.2014.15095
DO - 10.1001/jama.2014.15095
M3 - Article
C2 - 25399277
AN - SCOPUS:84911459193
SN - 0098-7484
VL - 312
SP - 2019
EP - 2027
JO - JAMA - Journal of the American Medical Association
JF - JAMA - Journal of the American Medical Association
IS - 19
ER -