Extending the resection beyond the contrast-enhancement for glioblastoma: feasibility, efficacy, and outcomes

David Mampre, Jeffrey Ehresman, Gabriel Pinilla-Monsalve, Maria Alejandra Gamboa Osorio, Alessandro Olivi, Alfredo Quinones-Hinojosa, Kaisorn L. Chaichana

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Object: It is becoming well-established that increasing extent of resection with decreasing residual volume is associated with delayed recurrence and prolonged survival for patients with glioblastoma (GBM). These prior studies are based on evaluating the contrast-enhancing (CE) tumour and not the surrounding fluid attenuated inversion recovery (FLAIR) volume. It therefore remains unclear if the resection beyond the CE portion of the tumour if it translates into improved outcomes for patients with GBM. Methods: Adult patients who underwent resection of a primary glioblastoma at a tertiary care institution between January 1, 2007 and December 31, 2012 and underwent radiation and temozolomide chemotherapy were retrospectively reviewed. Pre and postoperative MRI images were measured for CE tumour and FLAIR volumes. Multivariate proportional hazards were used to assess associations with both time to recurrence and death. Values with p < 0.05 were considered statistically significant. Results: 245 patients met the inclusion criteria. The median [IQR] preoperative CE and FLAIR tumour volumes were 31.9 [13.9–56.1] cm3 and 78.3 [44.7–115.6] cm3, respectively. Following surgery, the median [IQR] postoperative CE and FLAIR tumour volumes were 1.9 [0–7.1] cm3 and 59.7 [29.7–94.2] cm3, respectively. In multivariate analyses, the postoperative FLAIR volume was not associated with recurrence and/or survival (p > 0.05). However, the postoperative CE tumour volume was significantly associated with both recurrence [HR (95%CI); 1.026 (1.005–1.048), p= 0.01] and survival [HR (95%CI); 1.027 (1.007–1.032), p= 0.001]. The postoperative FLAIR volume was also not associated with recurrence and/or survival among patients who underwent gross total resection of the CE portion of the tumour as well as those who underwent supratotal resection. Conclusions: In this study, the volume of CE tumour remaining after resection is more important than FLAIR volume in regards to recurrence and survival for patients with GBM.

Original languageEnglish (US)
JournalBritish Journal of Neurosurgery
DOIs
StateAccepted/In press - Jan 1 2018

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Glioblastoma
Recurrence
Survival
temozolomide
Neoplasms
Residual Volume
Tertiary Healthcare
Tumor Burden
Radiation
Drug Therapy

Keywords

  • extent of resection
  • FLAIR volume
  • glioblastomas
  • supratotal resection

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this

Extending the resection beyond the contrast-enhancement for glioblastoma : feasibility, efficacy, and outcomes. / Mampre, David; Ehresman, Jeffrey; Pinilla-Monsalve, Gabriel; Osorio, Maria Alejandra Gamboa; Olivi, Alessandro; Quinones-Hinojosa, Alfredo; Chaichana, Kaisorn L.

In: British Journal of Neurosurgery, 01.01.2018.

Research output: Contribution to journalArticle

Mampre, David ; Ehresman, Jeffrey ; Pinilla-Monsalve, Gabriel ; Osorio, Maria Alejandra Gamboa ; Olivi, Alessandro ; Quinones-Hinojosa, Alfredo ; Chaichana, Kaisorn L. / Extending the resection beyond the contrast-enhancement for glioblastoma : feasibility, efficacy, and outcomes. In: British Journal of Neurosurgery. 2018.
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abstract = "Object: It is becoming well-established that increasing extent of resection with decreasing residual volume is associated with delayed recurrence and prolonged survival for patients with glioblastoma (GBM). These prior studies are based on evaluating the contrast-enhancing (CE) tumour and not the surrounding fluid attenuated inversion recovery (FLAIR) volume. It therefore remains unclear if the resection beyond the CE portion of the tumour if it translates into improved outcomes for patients with GBM. Methods: Adult patients who underwent resection of a primary glioblastoma at a tertiary care institution between January 1, 2007 and December 31, 2012 and underwent radiation and temozolomide chemotherapy were retrospectively reviewed. Pre and postoperative MRI images were measured for CE tumour and FLAIR volumes. Multivariate proportional hazards were used to assess associations with both time to recurrence and death. Values with p < 0.05 were considered statistically significant. Results: 245 patients met the inclusion criteria. The median [IQR] preoperative CE and FLAIR tumour volumes were 31.9 [13.9–56.1] cm3 and 78.3 [44.7–115.6] cm3, respectively. Following surgery, the median [IQR] postoperative CE and FLAIR tumour volumes were 1.9 [0–7.1] cm3 and 59.7 [29.7–94.2] cm3, respectively. In multivariate analyses, the postoperative FLAIR volume was not associated with recurrence and/or survival (p > 0.05). However, the postoperative CE tumour volume was significantly associated with both recurrence [HR (95{\%}CI); 1.026 (1.005–1.048), p= 0.01] and survival [HR (95{\%}CI); 1.027 (1.007–1.032), p= 0.001]. The postoperative FLAIR volume was also not associated with recurrence and/or survival among patients who underwent gross total resection of the CE portion of the tumour as well as those who underwent supratotal resection. Conclusions: In this study, the volume of CE tumour remaining after resection is more important than FLAIR volume in regards to recurrence and survival for patients with GBM.",
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T1 - Extending the resection beyond the contrast-enhancement for glioblastoma

T2 - feasibility, efficacy, and outcomes

AU - Mampre, David

AU - Ehresman, Jeffrey

AU - Pinilla-Monsalve, Gabriel

AU - Osorio, Maria Alejandra Gamboa

AU - Olivi, Alessandro

AU - Quinones-Hinojosa, Alfredo

AU - Chaichana, Kaisorn L.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Object: It is becoming well-established that increasing extent of resection with decreasing residual volume is associated with delayed recurrence and prolonged survival for patients with glioblastoma (GBM). These prior studies are based on evaluating the contrast-enhancing (CE) tumour and not the surrounding fluid attenuated inversion recovery (FLAIR) volume. It therefore remains unclear if the resection beyond the CE portion of the tumour if it translates into improved outcomes for patients with GBM. Methods: Adult patients who underwent resection of a primary glioblastoma at a tertiary care institution between January 1, 2007 and December 31, 2012 and underwent radiation and temozolomide chemotherapy were retrospectively reviewed. Pre and postoperative MRI images were measured for CE tumour and FLAIR volumes. Multivariate proportional hazards were used to assess associations with both time to recurrence and death. Values with p < 0.05 were considered statistically significant. Results: 245 patients met the inclusion criteria. The median [IQR] preoperative CE and FLAIR tumour volumes were 31.9 [13.9–56.1] cm3 and 78.3 [44.7–115.6] cm3, respectively. Following surgery, the median [IQR] postoperative CE and FLAIR tumour volumes were 1.9 [0–7.1] cm3 and 59.7 [29.7–94.2] cm3, respectively. In multivariate analyses, the postoperative FLAIR volume was not associated with recurrence and/or survival (p > 0.05). However, the postoperative CE tumour volume was significantly associated with both recurrence [HR (95%CI); 1.026 (1.005–1.048), p= 0.01] and survival [HR (95%CI); 1.027 (1.007–1.032), p= 0.001]. The postoperative FLAIR volume was also not associated with recurrence and/or survival among patients who underwent gross total resection of the CE portion of the tumour as well as those who underwent supratotal resection. Conclusions: In this study, the volume of CE tumour remaining after resection is more important than FLAIR volume in regards to recurrence and survival for patients with GBM.

AB - Object: It is becoming well-established that increasing extent of resection with decreasing residual volume is associated with delayed recurrence and prolonged survival for patients with glioblastoma (GBM). These prior studies are based on evaluating the contrast-enhancing (CE) tumour and not the surrounding fluid attenuated inversion recovery (FLAIR) volume. It therefore remains unclear if the resection beyond the CE portion of the tumour if it translates into improved outcomes for patients with GBM. Methods: Adult patients who underwent resection of a primary glioblastoma at a tertiary care institution between January 1, 2007 and December 31, 2012 and underwent radiation and temozolomide chemotherapy were retrospectively reviewed. Pre and postoperative MRI images were measured for CE tumour and FLAIR volumes. Multivariate proportional hazards were used to assess associations with both time to recurrence and death. Values with p < 0.05 were considered statistically significant. Results: 245 patients met the inclusion criteria. The median [IQR] preoperative CE and FLAIR tumour volumes were 31.9 [13.9–56.1] cm3 and 78.3 [44.7–115.6] cm3, respectively. Following surgery, the median [IQR] postoperative CE and FLAIR tumour volumes were 1.9 [0–7.1] cm3 and 59.7 [29.7–94.2] cm3, respectively. In multivariate analyses, the postoperative FLAIR volume was not associated with recurrence and/or survival (p > 0.05). However, the postoperative CE tumour volume was significantly associated with both recurrence [HR (95%CI); 1.026 (1.005–1.048), p= 0.01] and survival [HR (95%CI); 1.027 (1.007–1.032), p= 0.001]. The postoperative FLAIR volume was also not associated with recurrence and/or survival among patients who underwent gross total resection of the CE portion of the tumour as well as those who underwent supratotal resection. Conclusions: In this study, the volume of CE tumour remaining after resection is more important than FLAIR volume in regards to recurrence and survival for patients with GBM.

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KW - glioblastomas

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