Extended release of proteins following encapsulation in hydroxyapatite/chitosan composite scaffolds for bone tissue engineering applications

Declan M. Devine, Eilish Hoctor, Jessica S. Hayes, Eoin Sheehan, Christopher H. Evans

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Researchers describe a new strategy for extending the period of protein release within osseous lesions, by the covalent attachment of the proteins to scaffolds. In this context, they have developed a novel composite scaffold as a delivery vehicle. The composite scaffold was designed to be biomimetic, consisting of hydroxyapatite (HAp) which is similar to the mineral component of bone, in combination with the natural polymer chitosan (CS). HAp is used to enhance the load bearing capacity of the composite utilizing nanocomposite technology to produce a material which mimics the fine structure of natural bone. CS is used as an analog of collagen, which is the polymer phase of bone, and as a molecule to which proteins could be covalently bound.

Original languageEnglish (US)
Pages (from-to)281-289
Number of pages9
JournalMaterials Science and Engineering C
Volume84
DOIs
StatePublished - Mar 1 2018

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

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