The cyclin-dependent kinase inhibitors p16INK4/MTSl and p15INK4B/MTS2 have been mapped to a region in chromosome 9 (p21) that is deleted frequently in acute lymphoblastic leukemias and malignant gliomas. To gain insight into the functions of these inhibitors in lymphocytes and neuronal cells, we studied the expression of pl5 and pl6 during lymphocyte mitogenesis and neuronal differentiation. Expression of pl5 was extinguished during lymphocyte activation, concomitant with an increase in retinoblastoma kinase activity. The differentiation of the embryonic teratocarcinoma cell line NT2 into postmitotic neurons (hNT) was associated with enhanced expression of pl5 and pl6 proteins. These findings suggest that pl5 and pl6 play a role in maintaining cell quiescence in lymphocytes and neuronal cells, respectively. Deletions of these genes may thus promote unrestrained growth.
|Original language||English (US)|
|Number of pages||4|
|State||Published - Sep 15 1995|
ASJC Scopus subject areas
- Cancer Research