Expression of the p16 and p15 cyclin-dependent kinase inhibitors in lymphocyte activation and neuronal differentiation

A. F. Lois, Leslie T Jr. Cooper, Y. Geng, T. Nobori, D. Carson

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51 Citations (Scopus)

Abstract

The cyclin-dependent kinase inhibitors p16(INK4)/MTS1 and p15(INK4B)/MTS2 have been mapped to a region in chromosome 9 (p21) that is deleted frequently in acute lymphoblastic leukemias and malignant gliomas. To gain insight into the functions of these inhibitors in lymphocytes and neuronal cells, we studied the expression of p15 and p16 during lymphocyte mitogenesis and neuronal differentiation. Expression of p15 was extinguished during lymphocyte activation, concomitant with an increase in retinoblastoma kinase activity. The differentiation of the embryonic teratocarcinoma cell line NT2 into postmitotic neurons (hNT) was associated with enhanced expression of p15 and p16 proteins. These findings suggest that p15 and p16 play a role in maintaining cell quiescence in lymphocytes and neuronal cells, respectively. Deletions of these genes may thus promote unrestrained growth.

Original languageEnglish (US)
Pages (from-to)4010-4013
Number of pages4
JournalCancer Research
Volume55
Issue number18
StatePublished - 1995
Externally publishedYes

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Cyclin-Dependent Kinase Inhibitor p15
Cyclin-Dependent Kinase Inhibitor p16
Lymphocyte Activation
Lymphocytes
Teratocarcinoma
Chromosomes, Human, Pair 9
Retinoblastoma
Gene Deletion
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Glioma
Phosphotransferases
Neurons
Cell Line
Growth
Proteins

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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Expression of the p16 and p15 cyclin-dependent kinase inhibitors in lymphocyte activation and neuronal differentiation. / Lois, A. F.; Cooper, Leslie T Jr.; Geng, Y.; Nobori, T.; Carson, D.

In: Cancer Research, Vol. 55, No. 18, 1995, p. 4010-4013.

Research output: Contribution to journalArticle

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