Expression of the p16 and p15 Cyclin-dependent Kinase Inhibitors in Lymphocyte Activation and Neuronal Differentiation

Augusto F. Lois, Leslie T. Cooper, Yu Geng, Tsutomu Nobori, Dennis Carson

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The cyclin-dependent kinase inhibitors p16INK4/MTSl and p15INK4B/MTS2 have been mapped to a region in chromosome 9 (p21) that is deleted frequently in acute lymphoblastic leukemias and malignant gliomas. To gain insight into the functions of these inhibitors in lymphocytes and neuronal cells, we studied the expression of pl5 and pl6 during lymphocyte mitogenesis and neuronal differentiation. Expression of pl5 was extinguished during lymphocyte activation, concomitant with an increase in retinoblastoma kinase activity. The differentiation of the embryonic teratocarcinoma cell line NT2 into postmitotic neurons (hNT) was associated with enhanced expression of pl5 and pl6 proteins. These findings suggest that pl5 and pl6 play a role in maintaining cell quiescence in lymphocytes and neuronal cells, respectively. Deletions of these genes may thus promote unrestrained growth.

Original languageEnglish (US)
Pages (from-to)4010-4013
Number of pages4
JournalCancer research
Issue number18
StatePublished - Sep 15 1995


ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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