Expression of TCL-1 as a potential prognostic factor for treatment outcome in B-cell chronic lymphocytic leukemia

Rebekah L. Browning, Susan M. Geyer, Amy J. Johnson, Diane F. Jelinek, Renee C. Tschumper, Timothy G. Call, Tait D. Shanafelt, Clive S. Zent, Nancy D. Bone, Gordon W. Dewald, Thomas S. Lin, Nyla A. Heerema, Michael R. Grever, Neil E. Kay, John C. Byrd, David M. Lucas

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

TCL-1 expression is variable in CLL, and no study has examined its association with treatment response. We measured TCL-1 protein in CLL cells from 51 patients who then received pentostatin, cyclophosphamide, and rituximab. TCL-1 expression did not correlate with any pre-treatment characteristics. Lower TCL-1 levels were associated with higher probability of attaining flow cytometry-negative status post-treatment (52% versus 17%, p = 0.046). Trends toward improved complete remission rate (49% versus 19%, p = 0.064) and progression-free survival (medians: 33 versus 20 months, p = 0.199) were noted with lower TCL-1 expression. These data suggest TCL-1 expression may help predict treatment outcome in CLL patients following chemoimmunotherapy, and examination in larger studies is warranted.

Original languageEnglish (US)
Pages (from-to)1737-1740
Number of pages4
JournalLeukemia Research
Volume31
Issue number12
DOIs
StatePublished - Dec 2007

Keywords

  • Chemoimmunotherapy
  • Chronic lymphocytic leukemia (CLL)
  • Pentostatin
  • Prognostic factor
  • TCL-1

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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  • Cite this

    Browning, R. L., Geyer, S. M., Johnson, A. J., Jelinek, D. F., Tschumper, R. C., Call, T. G., Shanafelt, T. D., Zent, C. S., Bone, N. D., Dewald, G. W., Lin, T. S., Heerema, N. A., Grever, M. R., Kay, N. E., Byrd, J. C., & Lucas, D. M. (2007). Expression of TCL-1 as a potential prognostic factor for treatment outcome in B-cell chronic lymphocytic leukemia. Leukemia Research, 31(12), 1737-1740. https://doi.org/10.1016/j.leukres.2007.05.020