Expression of natural killer receptors in T- and NK-cells: comparison of healthy individuals, patients with prior stem cell transplant, and patients undergoing chemotherapy.

Horatiu Olteanu, Bernard C. Schur, Christopher Bredeson, Ehab Atallah, Steven H. Kroft

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

We studied the expression of natural killer receptors (NKRs) on peripheral blood cytotoxic T lymphocytes and NK cells in patients who underwent an allogeneic stem cell transplant (SCT), and compared these findings with results from healthy individuals (CTRL) and patients undergoing chemotherapy (CHEMO), respectively. Peripheral blood mononuclear cells were analyzed by flow cytometry with antibodies against the NKRs CD158a, CD158b, CD158e (known as killer immunoglobulin-like receptors, KIRs), and CD94. Expression of NKRs was evaluated separately in CD56+, CD57+, and CD56/CD57 (double+) subsets of T and NK cells. We found mainly differences in CD158a and CD94 expression between the three cohorts, with the SCT and CHEMO groups usually showing similar changes, when compared to the CTRL population. None of the patients with SCT or CHEMO demonstrated patterns of restricted NKR expression. Our results provide a comprehensive overview of KIR and CD94 expression in T and NK cells following SCT and chemotherapy.

Original languageEnglish (US)
Pages (from-to)481-487
Number of pages7
JournalLeukemia & lymphoma
Volume51
Issue number3
DOIs
StatePublished - Mar 1 2010

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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