Expression of individual ia specificities T and B cells: I. Studies with mitogen-induced blast cells*

Chella David, Tommaso Meo, John McCormick, Donald Shreffler

Research output: Contribution to journalArticlepeer-review

57 Scopus citations

Abstract

Ia specificities 1-10 were detected on LPS-stimulated splenic lymphocytes and on Con A-stimulated spleen, lymph node, and thymus blasts by direct cytotoxic tests. Since Ia antigens are not readily detectable on resting thymocytes, our results suggest that T cells require some signal before they exhibit full expression of Ia specificities. Absorption-elution studies indicated that most of the Ia specificities detected on T and B cells may be identical. Ia antigens detected by homologous antisera gave much stronger reactions than those detected by crossreacting antisera.

Original languageEnglish (US)
Pages (from-to)218-224
Number of pages7
JournalJournal of Experimental Medicine
Volume143
Issue number1
DOIs
StatePublished - Jan 1 1976

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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