Expression of I-region gene products on mouse tail epidermis cells

Christopher J. Krco; David Steinmuller; Chella S. David

doi:10.1016/0008-8749(79)90413-1

Expression of I-region gene products on mouse tail epidermis cells

Christopher J. Krco, David Steinmuller, Chella S. David

Immunology

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Mouse epidermal cells express Ia antigens. Epidermal cells from C3H and B10. A mice express I-A and I-E region gene products. Products associated with I-B and I-J were not detectable. A weak reaction was seen with anti-I-C sera. Products of the I-A region appear to be preferentially expressed when compared to I-E-region gene products. Ten percent of epidermal cells possess IgG-specific Fc receptors and 15% of epidermal cells can phagocytize latex particles. Our studies suggest that Ia-positive epidermal cells in mice are not necessarily limited to Langerhans cells.

Original language	English (US)
Pages (from-to)	239-246
Number of pages	8
Journal	Cellular Immunology
Volume	46
Issue number	2
DOIs	https://doi.org/10.1016/0008-8749(79)90413-1
State	Published - Sep 1 1979

ASJC Scopus subject areas

Immunology

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title = "Expression of I-region gene products on mouse tail epidermis cells",

abstract = "Mouse epidermal cells express Ia antigens. Epidermal cells from C3H and B10. A mice express I-A and I-E region gene products. Products associated with I-B and I-J were not detectable. A weak reaction was seen with anti-I-C sera. Products of the I-A region appear to be preferentially expressed when compared to I-E-region gene products. Ten percent of epidermal cells possess IgG-specific Fc receptors and 15% of epidermal cells can phagocytize latex particles. Our studies suggest that Ia-positive epidermal cells in mice are not necessarily limited to Langerhans cells.",

author = "Krco, {Christopher J.} and David Steinmuller and David, {Chella S.}",

note = "Funding Information: 1 This research was supported by grants from the National Diseases (AI 14764), National Cancer Institute (CA 24473), and supported by NIH Postdoctoral Fellowship AI-05584.",

year = "1979",

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doi = "10.1016/0008-8749(79)90413-1",

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T1 - Expression of I-region gene products on mouse tail epidermis cells

AU - Krco, Christopher J.

AU - Steinmuller, David

AU - David, Chella S.

N1 - Funding Information: 1 This research was supported by grants from the National Diseases (AI 14764), National Cancer Institute (CA 24473), and supported by NIH Postdoctoral Fellowship AI-05584.

PY - 1979/9/1

Y1 - 1979/9/1

N2 - Mouse epidermal cells express Ia antigens. Epidermal cells from C3H and B10. A mice express I-A and I-E region gene products. Products associated with I-B and I-J were not detectable. A weak reaction was seen with anti-I-C sera. Products of the I-A region appear to be preferentially expressed when compared to I-E-region gene products. Ten percent of epidermal cells possess IgG-specific Fc receptors and 15% of epidermal cells can phagocytize latex particles. Our studies suggest that Ia-positive epidermal cells in mice are not necessarily limited to Langerhans cells.

AB - Mouse epidermal cells express Ia antigens. Epidermal cells from C3H and B10. A mice express I-A and I-E region gene products. Products associated with I-B and I-J were not detectable. A weak reaction was seen with anti-I-C sera. Products of the I-A region appear to be preferentially expressed when compared to I-E-region gene products. Ten percent of epidermal cells possess IgG-specific Fc receptors and 15% of epidermal cells can phagocytize latex particles. Our studies suggest that Ia-positive epidermal cells in mice are not necessarily limited to Langerhans cells.

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Expression of I-region gene products on mouse tail epidermis cells

Abstract

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