Mouse epidermal cells express Ia antigens. Epidermal cells from C3H and B10. A mice express I-A and I-E region gene products. Products associated with I-B and I-J were not detectable. A weak reaction was seen with anti-I-C sera. Products of the I-A region appear to be preferentially expressed when compared to I-E-region gene products. Ten percent of epidermal cells possess IgG-specific Fc receptors and 15% of epidermal cells can phagocytize latex particles. Our studies suggest that Ia-positive epidermal cells in mice are not necessarily limited to Langerhans cells.
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