Expression of epidermal growth factor receptor in invasive transitional cell carcinoma of the urinary bladder: A multivariate survival analysis

P. L. Nguyen, P. E. Swanson, W. Jaszcz, D. M. Aeppli, G. Zhang, T. P. Singleton, S. Ward, D. Dykoski, J. Harvey, G. A. Niehans

Research output: Contribution to journalArticle

115 Scopus citations

Abstract

Epidermal growth factor receptor (EGFR) immunoreactivity was evaluated in 85 cases of invasive transitional cell carcinoma of the bladder. The impact of EGFR staining on patient survival was compared with tumor stage, histologic grade, immunoreactivity for c-erb B-2 and proliferating cell nuclear antigen, flow cytometrically determined S-phase fraction and DNA ploidy, abnormal expression of blood-group-related antigens, and patient blood type. Using a new monoclonal anti-EGFR antibody reactive in formalin- fixed tissue, the authors found a significant correlation between EGFR expression and high tumor stage, and between EGFR expression and poor patient outcome. However, EGFR expression as a predictor of prognosis was not independent of stage. An intriguing association between patient blood type and patient survival was noted. Other indices did not predict patient outcome after data were adjusted for stage.

Original languageEnglish (US)
Pages (from-to)166-176
Number of pages11
JournalAmerican Journal of Clinical Pathology
Volume101
Issue number2
StatePublished - 1994
Externally publishedYes

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Keywords

  • ABO blood type
  • Bladder cancer
  • DNA ploidy
  • Epidermal growth factor receptor
  • Immunohistochemistry
  • Transitional cell carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Nguyen, P. L., Swanson, P. E., Jaszcz, W., Aeppli, D. M., Zhang, G., Singleton, T. P., Ward, S., Dykoski, D., Harvey, J., & Niehans, G. A. (1994). Expression of epidermal growth factor receptor in invasive transitional cell carcinoma of the urinary bladder: A multivariate survival analysis. American Journal of Clinical Pathology, 101(2), 166-176.