Expression of 65-kd heat shock proteins in the inflammatory myopathies

R. Hohlfeld, Andrew G Engel

Research output: Contribution to journalArticle

21 Scopus citations


In normal muscle, 65-kd heat shock proteins (hsp) were detected on capillary endothelial cells, the mural elements of larger vessels, and some intracellular organelles, probably mitochondria. In the inflammatory myopathies, the 65-kd hsp were detected on inflammatory cells, degenerating and regenerating fibers, and on many but not all nonnecrotic muscle fibers invaded by T cells. The expression of the 65-kd hsp may be an immune- nonspecific response to cellular 'stress,' but hsp determinants could possibly also serve as autoantigen(s) recognized by autoreactive T cells.

Original languageEnglish (US)
Pages (from-to)821-823
Number of pages3
JournalAnnals of Neurology
Issue number6
StatePublished - 1992


ASJC Scopus subject areas

  • Neuroscience(all)

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