Expression and processing of amyloid precursor protein in vascular endothelium

Livius V. D’Uscio, Tongrong He, Zvonimir S Katusic

Research output: Contribution to journalReview article

11 Scopus citations

Abstract

Amyloid precursor protein (APP) is evolutionary conserved protein expressed in endothelial cells of cerebral and peripheral arteries. In this review, we discuss mechanisms responsible for expression and proteolytic cleavage of APP in endothelial cells. We focus on physiological and pathological implications of APP expression in vascular endothelium.

Original languageEnglish (US)
Pages (from-to)20-32
Number of pages13
JournalPhysiology
Volume32
Issue number1
DOIs
StatePublished - Jan 1 2017

ASJC Scopus subject areas

  • Physiology

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