Exposure to secondhand tobacco smoke and lung cancer by histological type: A pooled analysis of the International Lung Cancer Consortium (ILCCO)

Claire H. Kim, Yuan Chin Amy Lee, Rayjean J. Hung, Sheila R. McNallan, Michele L. Cote, Wei Yen Lim, Shen Chih Chang, Jin Hee Kim, Donatella Ugolini, Ying Chen, Triantafillos Liloglou, Angeline S. Andrew, Tracy Onega, Eric J. Duell, John K. Field, Philip Lazarus, Loic Le Marchand, Monica Neri, Paolo Vineis, Chikako KiyoharaYun Chul Hong, Hal Morgenstern, Keitaro Matsuo, Kazuo Tajima, David C. Christiani, John R. McLaughlin, Vladimir Bencko, Ivana Holcatova, Paolo Boffetta, Paul Brennan, Eleonora Fabianova, Lenka Foretova, Vladimir Janout, Jolanta Lissowska, Dana Mates, Peter Rudnai, Neonila Szeszenia-Dabrowska, Anush Mukeria, David Zaridze, Adeline Seow, Ann G. Schwartz, Ping Yang, Zuo Feng Zhang

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Abstract

While the association between exposure to secondhand smoke and lung cancer risk is well established, few studies with sufficient power have examined the association by histological type. In this study, we evaluated the secondhand smoke-lung cancer relationship by histological type based on pooled data from 18 case-control studies in the International Lung Cancer Consortium (ILCCO), including 2,504 cases and 7,276 control who were never smokers and 10,184 cases and 7,176 controls who were ever smokers. We used multivariable logistic regression, adjusting for age, sex, race/ethnicity, smoking status, pack-years of smoking, and study. Among never smokers, the odds ratios (OR) comparing those ever exposed to secondhand smoke with those never exposed were 1.31 (95% CI: 1.17-1.45) for all histological types combined, 1.26 (95% CI: 1.10-1.44) for adenocarcinoma, 1.41 (95% CI: 0.99-1.99) for squamous cell carcinoma, 1.48 (95% CI: 0.89-2.45) for large cell lung cancer, and 3.09 (95% CI: 1.62-5.89) for small cell lung cancer. The estimated association with secondhand smoke exposure was greater for small cell lung cancer than for nonsmall cell lung cancers (OR=2.11, 95% CI: 1.11-4.04). This analysis is the largest to date investigating the relation between exposure to secondhand smoke and lung cancer. Our study provides more precise estimates of the impact of secondhand smoke on the major histological types of lung cancer, indicates the association with secondhand smoke is stronger for small cell lung cancer than for the other histological types, and suggests the importance of intervention against exposure to secondhand smoke in lung cancer prevention.

Original languageEnglish (US)
Pages (from-to)1918-1930
Number of pages13
JournalInternational Journal of Cancer
Volume135
Issue number8
DOIs
StatePublished - Oct 15 2014

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Tobacco Smoke Pollution
Tobacco
Lung Neoplasms
Small Cell Lung Carcinoma
Smoking
Odds Ratio
Non-Small Cell Lung Carcinoma
Case-Control Studies
Squamous Cell Carcinoma
Adenocarcinoma
Logistic Models

Keywords

  • environmental tobacco smoke
  • International Lung Cancer Consortium
  • involuntary smoking
  • lung cancer
  • secondhand smoke

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Exposure to secondhand tobacco smoke and lung cancer by histological type : A pooled analysis of the International Lung Cancer Consortium (ILCCO). / Kim, Claire H.; Lee, Yuan Chin Amy; Hung, Rayjean J.; McNallan, Sheila R.; Cote, Michele L.; Lim, Wei Yen; Chang, Shen Chih; Kim, Jin Hee; Ugolini, Donatella; Chen, Ying; Liloglou, Triantafillos; Andrew, Angeline S.; Onega, Tracy; Duell, Eric J.; Field, John K.; Lazarus, Philip; Le Marchand, Loic; Neri, Monica; Vineis, Paolo; Kiyohara, Chikako; Hong, Yun Chul; Morgenstern, Hal; Matsuo, Keitaro; Tajima, Kazuo; Christiani, David C.; McLaughlin, John R.; Bencko, Vladimir; Holcatova, Ivana; Boffetta, Paolo; Brennan, Paul; Fabianova, Eleonora; Foretova, Lenka; Janout, Vladimir; Lissowska, Jolanta; Mates, Dana; Rudnai, Peter; Szeszenia-Dabrowska, Neonila; Mukeria, Anush; Zaridze, David; Seow, Adeline; Schwartz, Ann G.; Yang, Ping; Zhang, Zuo Feng.

In: International Journal of Cancer, Vol. 135, No. 8, 15.10.2014, p. 1918-1930.

Research output: Contribution to journalArticle

Kim, CH, Lee, YCA, Hung, RJ, McNallan, SR, Cote, ML, Lim, WY, Chang, SC, Kim, JH, Ugolini, D, Chen, Y, Liloglou, T, Andrew, AS, Onega, T, Duell, EJ, Field, JK, Lazarus, P, Le Marchand, L, Neri, M, Vineis, P, Kiyohara, C, Hong, YC, Morgenstern, H, Matsuo, K, Tajima, K, Christiani, DC, McLaughlin, JR, Bencko, V, Holcatova, I, Boffetta, P, Brennan, P, Fabianova, E, Foretova, L, Janout, V, Lissowska, J, Mates, D, Rudnai, P, Szeszenia-Dabrowska, N, Mukeria, A, Zaridze, D, Seow, A, Schwartz, AG, Yang, P & Zhang, ZF 2014, 'Exposure to secondhand tobacco smoke and lung cancer by histological type: A pooled analysis of the International Lung Cancer Consortium (ILCCO)', International Journal of Cancer, vol. 135, no. 8, pp. 1918-1930. https://doi.org/10.1002/ijc.28835
Kim, Claire H. ; Lee, Yuan Chin Amy ; Hung, Rayjean J. ; McNallan, Sheila R. ; Cote, Michele L. ; Lim, Wei Yen ; Chang, Shen Chih ; Kim, Jin Hee ; Ugolini, Donatella ; Chen, Ying ; Liloglou, Triantafillos ; Andrew, Angeline S. ; Onega, Tracy ; Duell, Eric J. ; Field, John K. ; Lazarus, Philip ; Le Marchand, Loic ; Neri, Monica ; Vineis, Paolo ; Kiyohara, Chikako ; Hong, Yun Chul ; Morgenstern, Hal ; Matsuo, Keitaro ; Tajima, Kazuo ; Christiani, David C. ; McLaughlin, John R. ; Bencko, Vladimir ; Holcatova, Ivana ; Boffetta, Paolo ; Brennan, Paul ; Fabianova, Eleonora ; Foretova, Lenka ; Janout, Vladimir ; Lissowska, Jolanta ; Mates, Dana ; Rudnai, Peter ; Szeszenia-Dabrowska, Neonila ; Mukeria, Anush ; Zaridze, David ; Seow, Adeline ; Schwartz, Ann G. ; Yang, Ping ; Zhang, Zuo Feng. / Exposure to secondhand tobacco smoke and lung cancer by histological type : A pooled analysis of the International Lung Cancer Consortium (ILCCO). In: International Journal of Cancer. 2014 ; Vol. 135, No. 8. pp. 1918-1930.
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T1 - Exposure to secondhand tobacco smoke and lung cancer by histological type

T2 - A pooled analysis of the International Lung Cancer Consortium (ILCCO)

AU - Kim, Claire H.

AU - Lee, Yuan Chin Amy

AU - Hung, Rayjean J.

AU - McNallan, Sheila R.

AU - Cote, Michele L.

AU - Lim, Wei Yen

AU - Chang, Shen Chih

AU - Kim, Jin Hee

AU - Ugolini, Donatella

AU - Chen, Ying

AU - Liloglou, Triantafillos

AU - Andrew, Angeline S.

AU - Onega, Tracy

AU - Duell, Eric J.

AU - Field, John K.

AU - Lazarus, Philip

AU - Le Marchand, Loic

AU - Neri, Monica

AU - Vineis, Paolo

AU - Kiyohara, Chikako

AU - Hong, Yun Chul

AU - Morgenstern, Hal

AU - Matsuo, Keitaro

AU - Tajima, Kazuo

AU - Christiani, David C.

AU - McLaughlin, John R.

AU - Bencko, Vladimir

AU - Holcatova, Ivana

AU - Boffetta, Paolo

AU - Brennan, Paul

AU - Fabianova, Eleonora

AU - Foretova, Lenka

AU - Janout, Vladimir

AU - Lissowska, Jolanta

AU - Mates, Dana

AU - Rudnai, Peter

AU - Szeszenia-Dabrowska, Neonila

AU - Mukeria, Anush

AU - Zaridze, David

AU - Seow, Adeline

AU - Schwartz, Ann G.

AU - Yang, Ping

AU - Zhang, Zuo Feng

PY - 2014/10/15

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N2 - While the association between exposure to secondhand smoke and lung cancer risk is well established, few studies with sufficient power have examined the association by histological type. In this study, we evaluated the secondhand smoke-lung cancer relationship by histological type based on pooled data from 18 case-control studies in the International Lung Cancer Consortium (ILCCO), including 2,504 cases and 7,276 control who were never smokers and 10,184 cases and 7,176 controls who were ever smokers. We used multivariable logistic regression, adjusting for age, sex, race/ethnicity, smoking status, pack-years of smoking, and study. Among never smokers, the odds ratios (OR) comparing those ever exposed to secondhand smoke with those never exposed were 1.31 (95% CI: 1.17-1.45) for all histological types combined, 1.26 (95% CI: 1.10-1.44) for adenocarcinoma, 1.41 (95% CI: 0.99-1.99) for squamous cell carcinoma, 1.48 (95% CI: 0.89-2.45) for large cell lung cancer, and 3.09 (95% CI: 1.62-5.89) for small cell lung cancer. The estimated association with secondhand smoke exposure was greater for small cell lung cancer than for nonsmall cell lung cancers (OR=2.11, 95% CI: 1.11-4.04). This analysis is the largest to date investigating the relation between exposure to secondhand smoke and lung cancer. Our study provides more precise estimates of the impact of secondhand smoke on the major histological types of lung cancer, indicates the association with secondhand smoke is stronger for small cell lung cancer than for the other histological types, and suggests the importance of intervention against exposure to secondhand smoke in lung cancer prevention.

AB - While the association between exposure to secondhand smoke and lung cancer risk is well established, few studies with sufficient power have examined the association by histological type. In this study, we evaluated the secondhand smoke-lung cancer relationship by histological type based on pooled data from 18 case-control studies in the International Lung Cancer Consortium (ILCCO), including 2,504 cases and 7,276 control who were never smokers and 10,184 cases and 7,176 controls who were ever smokers. We used multivariable logistic regression, adjusting for age, sex, race/ethnicity, smoking status, pack-years of smoking, and study. Among never smokers, the odds ratios (OR) comparing those ever exposed to secondhand smoke with those never exposed were 1.31 (95% CI: 1.17-1.45) for all histological types combined, 1.26 (95% CI: 1.10-1.44) for adenocarcinoma, 1.41 (95% CI: 0.99-1.99) for squamous cell carcinoma, 1.48 (95% CI: 0.89-2.45) for large cell lung cancer, and 3.09 (95% CI: 1.62-5.89) for small cell lung cancer. The estimated association with secondhand smoke exposure was greater for small cell lung cancer than for nonsmall cell lung cancers (OR=2.11, 95% CI: 1.11-4.04). This analysis is the largest to date investigating the relation between exposure to secondhand smoke and lung cancer. Our study provides more precise estimates of the impact of secondhand smoke on the major histological types of lung cancer, indicates the association with secondhand smoke is stronger for small cell lung cancer than for the other histological types, and suggests the importance of intervention against exposure to secondhand smoke in lung cancer prevention.

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KW - International Lung Cancer Consortium

KW - involuntary smoking

KW - lung cancer

KW - secondhand smoke

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