Exposure to early life stress regulates Bdnf expression in SERT mutant rats in an anatomically selective fashion

Francesca Calabrese, Rick H.A. Van Der Doelen, Gianluigi Guidotti, Giorgio Racagni, Tamas Kozicz, Judith R. Homberg, Marco A. Riva

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Although the causes of psychiatric disorders are not fully understood, it is well established that mental illness originates from the interaction between genetic and environmental factors. In this regard, compelling evidence demonstrates that depression can be the consequence of altered, and often maladaptive, response to adversities during pre- and early post-natal life. In this study, we investigated the impact of chronic maternal separation (MS) on the expression of the neurotrophin brain-derived neurotrophic factor (BDNF) in serotonin transporter (SERT) knockout rats in the ventral and dorsal hippocampus as well as the ventromedial and dorsomedial prefrontal cortex (PFC). We found that both SERT deletion and the MS led to an overall reduction in Bdnf expression in the ventral hippocampus and the ventromedial PFC, whereas in the dorsal hippocampus and in the dorsomedial PFC, we observed a significant increase in the neurotrophin gene expression after MS exposure, specifically in the heterozygous SERT rats. In summary, we show that the modulation of Bdnf expression in SERT mutant rats exposed to MS reflects the complex functional consequences of this gene-environment interaction with a clear distinction between the ventral and the dorsal subfields of the hippocampus and of the PFC.

Original languageEnglish (US)
Pages (from-to)146-154
Number of pages9
JournalJournal of Neurochemistry
Volume132
Issue number1
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

Fingerprint

Serotonin Plasma Membrane Transport Proteins
Prefrontal Cortex
Psychological Stress
Rats
Hippocampus
Mothers
Nerve Growth Factors
Maternal Exposure
Gene-Environment Interaction
Brain-Derived Neurotrophic Factor
Gene expression
Psychiatry
Genes
Modulation
Depression
Gene Expression

Keywords

  • maternal separation
  • neurotrophin
  • serotonin
  • ventral and dorsal hippocampus/prefrontal cortex

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

Cite this

Calabrese, F., Van Der Doelen, R. H. A., Guidotti, G., Racagni, G., Kozicz, T., Homberg, J. R., & Riva, M. A. (2015). Exposure to early life stress regulates Bdnf expression in SERT mutant rats in an anatomically selective fashion. Journal of Neurochemistry, 132(1), 146-154. https://doi.org/10.1111/jnc.12846

Exposure to early life stress regulates Bdnf expression in SERT mutant rats in an anatomically selective fashion. / Calabrese, Francesca; Van Der Doelen, Rick H.A.; Guidotti, Gianluigi; Racagni, Giorgio; Kozicz, Tamas; Homberg, Judith R.; Riva, Marco A.

In: Journal of Neurochemistry, Vol. 132, No. 1, 01.01.2015, p. 146-154.

Research output: Contribution to journalArticle

Calabrese, F, Van Der Doelen, RHA, Guidotti, G, Racagni, G, Kozicz, T, Homberg, JR & Riva, MA 2015, 'Exposure to early life stress regulates Bdnf expression in SERT mutant rats in an anatomically selective fashion', Journal of Neurochemistry, vol. 132, no. 1, pp. 146-154. https://doi.org/10.1111/jnc.12846
Calabrese, Francesca ; Van Der Doelen, Rick H.A. ; Guidotti, Gianluigi ; Racagni, Giorgio ; Kozicz, Tamas ; Homberg, Judith R. ; Riva, Marco A. / Exposure to early life stress regulates Bdnf expression in SERT mutant rats in an anatomically selective fashion. In: Journal of Neurochemistry. 2015 ; Vol. 132, No. 1. pp. 146-154.
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