Exposure of hepatitis C virus-negative recipients to ≥ 2 infected blood donors

T. Laskus, L. F. Wang, M. Radkowski, M. Nowicki, J. Wilkinson, Jorge Rakela

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

This study analyzed 4 cases of hepatitis C virus (HCV)-naive transfusion recipients who developed hepatitis after receiving blood from >1 HCV-infected donor. One recipient was exposed to 4 donors, 2 were exposed to 3 donors, and 1 was exposed to 2 donors. For 3 recipients, the strain from 1 of the donors predominated in all follow-up samples collected for 8-40 months. For 2 recipients, the strain from the second donor was occasionally detectable with sensitive strain-specific assays. For the fourth recipient, the initially dominant strain was later supplanted by a strain from the other donor. Simultaneous exposure to multiple HCV strains may result in concomitant infection by >1 strain, although a single strain rapidly establishes its dominance. These observations are compatible with the presence of competition among infecting HCV strains that results in the dominance of 1 strain and competitive exclusion or suppression of other strains.

Original languageEnglish (US)
Pages (from-to)666-669
Number of pages4
JournalJournal of Infectious Diseases
Volume183
Issue number4
DOIs
StatePublished - Feb 15 2001

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Blood Donors
Hepacivirus
Tissue Donors
Hepatitis
Infection

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Exposure of hepatitis C virus-negative recipients to ≥ 2 infected blood donors. / Laskus, T.; Wang, L. F.; Radkowski, M.; Nowicki, M.; Wilkinson, J.; Rakela, Jorge.

In: Journal of Infectious Diseases, Vol. 183, No. 4, 15.02.2001, p. 666-669.

Research output: Contribution to journalArticle

Laskus, T, Wang, LF, Radkowski, M, Nowicki, M, Wilkinson, J & Rakela, J 2001, 'Exposure of hepatitis C virus-negative recipients to ≥ 2 infected blood donors', Journal of Infectious Diseases, vol. 183, no. 4, pp. 666-669. https://doi.org/10.1086/318531
Laskus, T. ; Wang, L. F. ; Radkowski, M. ; Nowicki, M. ; Wilkinson, J. ; Rakela, Jorge. / Exposure of hepatitis C virus-negative recipients to ≥ 2 infected blood donors. In: Journal of Infectious Diseases. 2001 ; Vol. 183, No. 4. pp. 666-669.
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