@article{6f7c545ddcc6492aa35ae04b39761bcd,
title = "Exploring therapeutic decisions in elderly patients with non-small cell lung cancer: Results and conclusions from North central cancer treatment group study N0222",
abstract = "How do oncologists choose therapy for the elderly? Oncologists assigned patients aged 65 years or older with incurable non-small cell lung cancer to: (a) carboplatin (AUC = 2) + paclitaxel 50 mg/m2 days 1, 8, 15 (28-day cycle ×A - 4) followed by gefitinib; or (b) gefitinib 250 mg/day. With (a), 12 of 34 were progression-free at 6 months; median time to cancer progression was 3.9 months. With (b), the same occurred in 11 of 28 patients with the latter being 4.9 months. The most common reason for conventional chemotherapy was oncologists opinion that the cancer was aggressive, and for gefitinib alone, patients reluctance to receive chemotherapy. Interestingly, age had no influence.",
keywords = "Akt, Breast cancer, Mutation, PI3K, PIK3CA",
author = "{Mc Kean}, Heidi and Stella, {Philip J.} and Hillman, {Shauna L.} and Rowland, {Kendrith M.} and Cannon, {Michael W.} and Behrens, {Robert J.} and Gross, {Gerald G.} and Sborov, {Mark D.} and Friedman, {Eliot L.} and Aminah Jatoi",
note = "Funding Information: This study was conducted as a collaborative trial of the North Central Cancer Treatment Group and Mayo Clinic and was supported in part by Public Health Service grants: CA-25224, CA-37404, CA-15083, CA-35195, CA-35431, CA-35101, CA-37417, CA-35267, CA-35448, CA-35103, CA-52352, CA-35113, and CA-35090. The content is solely the responsibility of the authors and does not necessarily represent the views of the National Cancer Institute or the National Institute of Health. This study was also supported by 5K24CA131099 to A.J.The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.",
year = "2011",
month = may,
doi = "10.3109/07357907.2010.535061",
language = "English (US)",
volume = "29",
pages = "266--271",
journal = "Cancer Investigation",
issn = "0735-7907",
publisher = "Informa Healthcare",
number = "4",
}