Exploring the role of inflammation in the malignant transformation of low-grade gliomas

Nicole Michelson, Jordina Rincon-Torroella, Alfredo Quinones-Hinojosa, Jeffrey P. Greenfield

Research output: Contribution to journalReview article

24 Scopus citations

Abstract

Studies of inflammatory mediators have established the tumor micro-environment as a driver of oncogenesis. This inflammatory milieu often precedes cancer, however recent data also point to the ability of oncogenic changes to induce inflammatory responses that are later harnessed by the tumor to survive and proliferate. In this review, we propose that the IDH1 mutation, present in the majority of low-grade gliomas (LGGs), initiates an inflammatory cascade that is ultimately hijacked by the tumor. Glioma infiltrating macrophages and microglia (GIMs) are polarized to the M2 phenotype, subverting the host's adaptive immune response, and fostering a tumor milieu ripe for angiogenesis, migration, and metastasis. As data continue to expand the role of inflammation in low-grade gliomas, new molecular pathways may emerge as therapeutic targets that offer a window of opportunity to intervene before the malignant transformation (MT) of LGGs occurs.

Original languageEnglish (US)
Pages (from-to)132-140
Number of pages9
JournalJournal of Neuroimmunology
Volume297
DOIs
StatePublished - Aug 15 2016
Externally publishedYes

Keywords

  • IDH1 mutation
  • Inflammation
  • Low-grade gliomas
  • Macrophages
  • Malignant transformation
  • Microglia

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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