Exploring the overlap between multiple sclerosis, tumefactive demyelination and Baló's concentric sclerosis

Research output: Contribution to journalReview article

20 Scopus citations

Abstract

The availability of magnetic resonance imaging (MRI) has led to increasing recognition that multiple sclerosis (MS), tumefactive demyelination (TD) and Baló's concentric sclerosis (BCS) share many overlapping features. Baló-like lesions, which exhibit limited features of BCS, may represent an intermediate between BCS and typical MS demyelination. Lesions labeled as tumefactive are typically larger, but otherwise have much in common with conventional MS lesions, and TD and BCS lesions can also overlap. In this article, we explore the similarities between typical MS, TD and BCS cases, and reflect on the potential insights that intermediate or overlapping phenotypes may contribute towards an understanding of MS immunopathogenesis, and question whether these atypical forms of demyelination should be classified as separate demyelinating diseases, as different lesional manifestations of demyelination of any cause or as part of a spectrum with conventional MS.

Original languageEnglish (US)
Pages (from-to)986-992
Number of pages7
JournalMultiple Sclerosis
Volume22
Issue number8
DOIs
StatePublished - Jul 1 2016

Keywords

  • atypical
  • Histopathology
  • immunopathogenesis
  • newly forming
  • pseudotumor

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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