Exploring the neuroregenerative potential of tacrolimus

T. M. Saffari, M. Bedar, J. M. Zuidam, A. Y. Shin, C. C. Baan, D. A. Hesselink, C. A. Hundepool

Research output: Contribution to journalReview article

2 Scopus citations

Abstract

Introduction: The clinical use of tacrolimus is characterized by many side effects which include neurotoxicity. In contrast, tacrolimus has also shown to have neuroregenerative properties. On a molecular level, the mechanisms of action could provide us more insight into understanding the neurobiological effects. The aim of this article is to review current evidence regarding the use of tacrolimus in peripheral nerve injuries. Areas covered: Available data on tacrolimus’ indications were summarized and molecular mechanisms were elucidated to possibly understand the conflicting neurotoxic and neuroregenerative effects. The potential clinical applications of tacrolimus, as immunosuppressant and enhancer of nerve regeneration in peripheral nerve injuries, are discussed. Finally, concepts of delivery are explored. Expert opinion: It is unclear what the exact neurobiological effects of tacrolimus are. Besides its known calcineurin inhibiting properties, the mechanism of action of tacrolimus is mediated by its binding to FK506-binding protein-52, resulting in a bimodal dose response. Experimental models found that tacrolimus administration is preferred up to three days prior to or within 10 days post-nerve reconstruction. Moreover, the indication for the use of tacrolimus has been expanding to fields of dermatology, ophthalmology, orthopedic surgery and rheumatology to improve outcomes after various indications.

Original languageEnglish (US)
Pages (from-to)1047-1057
Number of pages11
JournalExpert Review of Clinical Pharmacology
Volume12
Issue number11
DOIs
StatePublished - Nov 2 2019

Keywords

  • allograft rejection
  • Calcineurin inhibitor
  • nerve injury
  • neuroregeneration
  • neurotoxicity
  • tacrolimus
  • transplantation

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)

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  • Cite this

    Saffari, T. M., Bedar, M., Zuidam, J. M., Shin, A. Y., Baan, C. C., Hesselink, D. A., & Hundepool, C. A. (2019). Exploring the neuroregenerative potential of tacrolimus. Expert Review of Clinical Pharmacology, 12(11), 1047-1057. https://doi.org/10.1080/17512433.2019.1675507