Exploring the concordance of aspergillus fumigatus pathogenicity in mice and Toll-deficient flies

Georgios Chamilos, Elaine M. Bignell, Markus Schrettl, Russell E. Lewis, Konstantinos Leventakos, Gregory S. May, Hubertus Haas, Dimitrios P. Kontoyiannis

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

The pathogenicity of six mutants of Aspergillus fumigatus that had been previously characterized in mice was assessed in Toll-deficient Drosophila melanogaster flies. Four out of six mutants of A. fumigatus, which displayed attenuated virulence in mice due to defects in siderophore biosynthesis (ΔsidA, ΔsidD), PABA metabolism (H515), and starvation stress response (ΔcpcA), also had attenuated virulence in the fly model. In addition, similarly to previous findings in the mouse model, ΔsidG mutant that is defective in extracellular siderophore biosynthesis retained full virulence in Toll-deficient flies. Overall, our studies reveal a high level of concordance between fly and murine models of invasive aspergillosis.

Original languageEnglish (US)
Pages (from-to)506-510
Number of pages5
JournalMedical mycology
Volume48
Issue number3
DOIs
StatePublished - Apr 14 2010

Keywords

  • Aspergillus
  • Drosophila melanogaster
  • Invertebrates
  • Toll receptor
  • Virulence

ASJC Scopus subject areas

  • Infectious Diseases

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    Chamilos, G., Bignell, E. M., Schrettl, M., Lewis, R. E., Leventakos, K., May, G. S., Haas, H., & Kontoyiannis, D. P. (2010). Exploring the concordance of aspergillus fumigatus pathogenicity in mice and Toll-deficient flies. Medical mycology, 48(3), 506-510. https://doi.org/10.3109/13693780903225813