Expiratory loading improves cardiac output during exercise in heart failure

Sophie Lalande, Charles E. Luoma, Andrew D. Miller, Bruce David Johnson

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

PURPOSE: The objective of this study was to investigate the effect of changes in expiratory intrathoracic pressure on stroke volume (SV) at rest and during moderate exercise in patients with heart failure versus healthy individuals. METHODS: SV was obtained by echocardiography during spontaneous breathing and during expiratory loads of 5 and 10 cm H2O produced by a ventilator in 11 patients with heart failure (61 ± yr, ejection fraction: 32 ± 4%, New York Heart Association, 32% ± 4%; NYHA class I-II) and 11 age-matched healthy individuals at rest and during exercise at 60% of aerobic capacity on a semirecumbent cycle ergometer. RESULTS: At rest, expiratory loading did not change HR, SV index (SVI), or cardiac index (CI) in either group. During moderate exercise, expiratory loading increased SVI and CI in patients with heart failure but decreased SVI and CI in healthy individuals. There was a negative correlation between changes in gastric pressure and SVI (r = -0.51, P < 0.05) in healthy individuals, whereas there was a positive correlation between changes in gastric pressure accompanying expiratory loading and CI (r = 0.83, P < 0.01) in patients with heart failure. CONCLUSION: Expiratory loading during moderate exercise elicited increases in SVI and CI in patients with heart failure but decreased SVI and CI in healthy individuals. Improvements in cardiac function during submaximal exercise in patients with heart failure may be caused by a beneficial reduction in left ventricular preload.

Original languageEnglish (US)
Pages (from-to)2309-2314
Number of pages6
JournalMedicine and Science in Sports and Exercise
Volume44
Issue number12
DOIs
StatePublished - Dec 2012

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Cardiac Output
Heart Failure
Exercise
Stroke Volume
Pressure
Stomach
Mechanical Ventilators
Echocardiography
Respiration

Keywords

  • Cardiorespiratory
  • Exercise tolerance
  • Preload
  • Stroke volume

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Expiratory loading improves cardiac output during exercise in heart failure. / Lalande, Sophie; Luoma, Charles E.; Miller, Andrew D.; Johnson, Bruce David.

In: Medicine and Science in Sports and Exercise, Vol. 44, No. 12, 12.2012, p. 2309-2314.

Research output: Contribution to journalArticle

Lalande, Sophie ; Luoma, Charles E. ; Miller, Andrew D. ; Johnson, Bruce David. / Expiratory loading improves cardiac output during exercise in heart failure. In: Medicine and Science in Sports and Exercise. 2012 ; Vol. 44, No. 12. pp. 2309-2314.
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