Expert consensus for multi-modality imaging evaluation of cardiovascular complications of radiotherapy in adults

a report from the European Association of Cardiovascular Imaging and the American Society of Echocardiography.

Patrizio Lancellotti, Vuyisile T Nkomo, Luigi P. Badano, Jutta Bergler-Klein, Jan Bogaert, Laurent Davin, Bernard Cosyns, Philippe Coucke, Raluca Dulgheru, Thor Edvardsen, Oliver Gaemperli, Maurizio Galderisi, Brian Griffin, Paul A. Heidenreich, Koen Nieman, Juan C. Plana, Steven C. Port, Marielle Scherrer-Crosbie, Ronald G. Schwartz, Igal A. Sebag & 6 others Jens Uwe Voigt, Samuel Wann, Phillip C. Yang, Society of Nuclear Cardiology American Society of Nuclear Cardiology, for Cardiovascular Magnetic Resonance Society for Cardiovascular Magnetic Resonance, of Cardiovascular Computed Tomography Society of Cardiovascular Computed Tomography

Research output: Contribution to journalArticle

129 Citations (Scopus)

Abstract

Cardiac toxicity is one of the most concerning side effects of anti-cancer therapy. The gain in life expectancy obtained with anti-cancer therapy can be compromised by increased morbidity and mortality associated with its cardiac complications. While radiosensitivity of the heart was initially recognized only in the early 1970s, the heart is regarded in the current era as one of the most critical dose-limiting organs in radiotherapy. Several clinical studies have identified adverse clinical consequences of radiation-induced heart disease (RIHD) on the outcome of long-term cancer survivors. A comprehensive review of potential cardiac complications related to radiotherapy is warranted. An evidence-based review of several imaging approaches used to detect, evaluate, and monitor RIHD is discussed. Recommendations for the early identification and monitoring of cardiovascular complications of radiotherapy by cardiac imaging are also proposed.

Original languageEnglish (US)
Pages (from-to)721-740
Number of pages20
JournalEuropean Heart Journal Cardiovascular Imaging
Volume14
Issue number8
StatePublished - Aug 2013

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Radiotherapy
Heart Diseases
Radiation
Neoplasms
Radiation Tolerance
Life Expectancy
Survivors
Morbidity
Mortality
Therapeutics
Cardiotoxicity
Clinical Studies

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

Cite this

Expert consensus for multi-modality imaging evaluation of cardiovascular complications of radiotherapy in adults : a report from the European Association of Cardiovascular Imaging and the American Society of Echocardiography. / Lancellotti, Patrizio; Nkomo, Vuyisile T; Badano, Luigi P.; Bergler-Klein, Jutta; Bogaert, Jan; Davin, Laurent; Cosyns, Bernard; Coucke, Philippe; Dulgheru, Raluca; Edvardsen, Thor; Gaemperli, Oliver; Galderisi, Maurizio; Griffin, Brian; Heidenreich, Paul A.; Nieman, Koen; Plana, Juan C.; Port, Steven C.; Scherrer-Crosbie, Marielle; Schwartz, Ronald G.; Sebag, Igal A.; Voigt, Jens Uwe; Wann, Samuel; Yang, Phillip C.; American Society of Nuclear Cardiology, Society of Nuclear Cardiology; Society for Cardiovascular Magnetic Resonance, for Cardiovascular Magnetic Resonance; Society of Cardiovascular Computed Tomography, of Cardiovascular Computed Tomography.

In: European Heart Journal Cardiovascular Imaging, Vol. 14, No. 8, 08.2013, p. 721-740.

Research output: Contribution to journalArticle

Lancellotti, P, Nkomo, VT, Badano, LP, Bergler-Klein, J, Bogaert, J, Davin, L, Cosyns, B, Coucke, P, Dulgheru, R, Edvardsen, T, Gaemperli, O, Galderisi, M, Griffin, B, Heidenreich, PA, Nieman, K, Plana, JC, Port, SC, Scherrer-Crosbie, M, Schwartz, RG, Sebag, IA, Voigt, JU, Wann, S, Yang, PC, American Society of Nuclear Cardiology, SONC, Society for Cardiovascular Magnetic Resonance, FCMR & Society of Cardiovascular Computed Tomography, OCCT 2013, 'Expert consensus for multi-modality imaging evaluation of cardiovascular complications of radiotherapy in adults: a report from the European Association of Cardiovascular Imaging and the American Society of Echocardiography.', European Heart Journal Cardiovascular Imaging, vol. 14, no. 8, pp. 721-740.
Lancellotti, Patrizio ; Nkomo, Vuyisile T ; Badano, Luigi P. ; Bergler-Klein, Jutta ; Bogaert, Jan ; Davin, Laurent ; Cosyns, Bernard ; Coucke, Philippe ; Dulgheru, Raluca ; Edvardsen, Thor ; Gaemperli, Oliver ; Galderisi, Maurizio ; Griffin, Brian ; Heidenreich, Paul A. ; Nieman, Koen ; Plana, Juan C. ; Port, Steven C. ; Scherrer-Crosbie, Marielle ; Schwartz, Ronald G. ; Sebag, Igal A. ; Voigt, Jens Uwe ; Wann, Samuel ; Yang, Phillip C. ; American Society of Nuclear Cardiology, Society of Nuclear Cardiology ; Society for Cardiovascular Magnetic Resonance, for Cardiovascular Magnetic Resonance ; Society of Cardiovascular Computed Tomography, of Cardiovascular Computed Tomography. / Expert consensus for multi-modality imaging evaluation of cardiovascular complications of radiotherapy in adults : a report from the European Association of Cardiovascular Imaging and the American Society of Echocardiography. In: European Heart Journal Cardiovascular Imaging. 2013 ; Vol. 14, No. 8. pp. 721-740.
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abstract = "Cardiac toxicity is one of the most concerning side effects of anti-cancer therapy. The gain in life expectancy obtained with anti-cancer therapy can be compromised by increased morbidity and mortality associated with its cardiac complications. While radiosensitivity of the heart was initially recognized only in the early 1970s, the heart is regarded in the current era as one of the most critical dose-limiting organs in radiotherapy. Several clinical studies have identified adverse clinical consequences of radiation-induced heart disease (RIHD) on the outcome of long-term cancer survivors. A comprehensive review of potential cardiac complications related to radiotherapy is warranted. An evidence-based review of several imaging approaches used to detect, evaluate, and monitor RIHD is discussed. Recommendations for the early identification and monitoring of cardiovascular complications of radiotherapy by cardiac imaging are also proposed.",
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