Expert consensus document: Advances in the diagnosis and classification of gastric and intestinal motility disorders

Jutta Keller, Gabrio Bassotti, John Clarke, Phil Dinning, Mark Fox, Madhusudan Grover, Per M. Hellström, Meiyun Ke, Peter Layer, Carolina Malagelada, Henry P. Parkman, S. Mark Scott, Jan Tack, Magnus Simren, Hans Törnblom, Michael Camilleri

Research output: Contribution to journalReview article

42 Scopus citations

Abstract

Disturbances of gastric, intestinal and colonic motor and sensory functions affect a large proportion of the population worldwide, impair quality of life and cause considerable health-care costs. Assessment of gastrointestinal motility in these patients can serve to establish diagnosis and to guide therapy. Major advances in diagnostic techniques during the past 5-10 years have led to this update about indications for and selection and performance of currently available tests. As symptoms have poor concordance with gastrointestinal motor dysfunction, clinical motility testing is indicated in patients in whom there is no evidence of causative mucosal or structural diseases such as inflammatory or malignant disease. Transit tests using radiopaque markers, scintigraphy, breath tests and wireless motility capsules are noninvasive. Other tests of gastrointestinal contractility or sensation usually require intubation, typically represent second-line investigations limited to patients with severe symptoms and are performed at only specialized centres. This Consensus Statement details recommended tests as well as useful clinical alternatives for investigation of gastric, small bowel and colonic motility. The article provides recommendations on how to classify gastrointestinal motor disorders on the basis of test results and describes how test results guide treatment decisions.

Original languageEnglish (US)
Pages (from-to)291-308
Number of pages18
JournalNature Reviews Gastroenterology and Hepatology
Volume15
Issue number5
DOIs
StatePublished - May 1 2018

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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    Keller, J., Bassotti, G., Clarke, J., Dinning, P., Fox, M., Grover, M., Hellström, P. M., Ke, M., Layer, P., Malagelada, C., Parkman, H. P., Scott, S. M., Tack, J., Simren, M., Törnblom, H., & Camilleri, M. (2018). Expert consensus document: Advances in the diagnosis and classification of gastric and intestinal motility disorders. Nature Reviews Gastroenterology and Hepatology, 15(5), 291-308. https://doi.org/10.1038/nrgastro.2018.7