Abstract
The improvement of imaging techniques over the years has contributed to the understanding of the natural history of autosomal dominant polycystic kidney disease, and facilitated the observation of its structural progression. Advances in molecular biology and genetics have made possible a greater understanding of the genetics, molecular, and cellular pathophysiologic mechanisms responsible for its development and have laid the foundation for the development of potential new therapies. Therapies targeting genetic mechanisms in ADPKD have inherent limitations. As a result, most experimental therapies at the present time are aimed at delaying the growth of the cysts and associated interstitial inflammation and fibrosis by targeting tubular epithelial cell proliferation and fluid secretion by the cystic epithelium. Several interventions affecting many of the signaling pathways disrupted in ADPKD have been effective in animal models and some are currently being tested in clinical trials.
Original language | English (US) |
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Pages (from-to) | 44-59 |
Number of pages | 16 |
Journal | Current Hypertension Reviews |
Volume | 9 |
Issue number | 1 |
DOIs | |
State | Published - 2013 |
Keywords
- AMP-activated protein kinase (AMPK) activators
- Autosomal dominant polycystic kidney disease
- Cystic fibrosis transmembrane conductance regulator (CFTR) inhibitors
- Mammalian target of rapamycin (mTOR) inhibitors
- Somatostatin analogues
- Src inhibitors
ASJC Scopus subject areas
- Internal Medicine