Experimental side-wall aneurysms: A natural history study

David F Kallmes, T. A. Altes, D. A. Vincent, H. J. Cloft, H. M. Do, M. E. Jensen

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

We studied the natural history of canine side-wall experimental aneurysms to determine the incidence of spontaneous aneurysm thrombosis, to serve as control data for future studies focusing on development of aneurysm occlusion devices. Bilateral common carotid artery vein patch aneurysms were surgically created in eight mongrel dogs (20-25 kg). Duplex Doppler sonography was performed at 14 days and angiography between 30 and 210 days following aneurysm creation. Sonography demonstrated patency of 13 (81%) of 16 aneurysms. Patent aneurysms ranged in size from 8 x 10 mm to 14 x 16 mm. Conventional angiography was performed in four dogs approximately 30 days following aneurysm creation; in these four, all of 7 initially patent on sonography remained fully patent. One dog underwent conventional angiography at approximately 60 days following aneurysm creation; both aneurysms in this case remained widely patent. Three dogs underwent conventional angiography at approximately 200 days following aneurysm creation; all 4 aneurysms initially patent on sonography remained fully patent. None of the three aneurysms found to be occluded on sonographs demonstrated spontaneous recanalization. The canine side-wall aneurysm model is a valid tool for testing some aneurysm-occlusion devices, because control aneurysms remain patent indefinitely.

Original languageEnglish (US)
Pages (from-to)338-341
Number of pages4
JournalNeuroradiology
Volume41
Issue number5
DOIs
StatePublished - May 1999
Externally publishedYes

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Natural History
Aneurysm
Angiography
Dogs
Ultrasonography
Canidae
Doppler Duplex Ultrasonography
Equipment and Supplies
Common Carotid Artery
Veins

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Kallmes, D. F., Altes, T. A., Vincent, D. A., Cloft, H. J., Do, H. M., & Jensen, M. E. (1999). Experimental side-wall aneurysms: A natural history study. Neuroradiology, 41(5), 338-341. https://doi.org/10.1007/s002340050760

Experimental side-wall aneurysms : A natural history study. / Kallmes, David F; Altes, T. A.; Vincent, D. A.; Cloft, H. J.; Do, H. M.; Jensen, M. E.

In: Neuroradiology, Vol. 41, No. 5, 05.1999, p. 338-341.

Research output: Contribution to journalArticle

Kallmes, DF, Altes, TA, Vincent, DA, Cloft, HJ, Do, HM & Jensen, ME 1999, 'Experimental side-wall aneurysms: A natural history study', Neuroradiology, vol. 41, no. 5, pp. 338-341. https://doi.org/10.1007/s002340050760
Kallmes DF, Altes TA, Vincent DA, Cloft HJ, Do HM, Jensen ME. Experimental side-wall aneurysms: A natural history study. Neuroradiology. 1999 May;41(5):338-341. https://doi.org/10.1007/s002340050760
Kallmes, David F ; Altes, T. A. ; Vincent, D. A. ; Cloft, H. J. ; Do, H. M. ; Jensen, M. E. / Experimental side-wall aneurysms : A natural history study. In: Neuroradiology. 1999 ; Vol. 41, No. 5. pp. 338-341.
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