Experimental mucosal infection with molecularly cloned feline immunodeficiency viruses

Mariko Kohmoto; Yasuhiro Ikeda; Eiji Sato; Yorihiro Nishimura; Yasuo Inoshima; Masayuki Shimojima; Yukinobu Tohya; Takeshi Mikami; Takayuki Miyazawa

doi:10.1128/CDLI.10.1.185-188.2003

Experimental mucosal infection with molecularly cloned feline immunodeficiency viruses

Mariko Kohmoto, Yasuhiro Ikeda, Eiji Sato, Yorihiro Nishimura, Yasuo Inoshima, Masayuki Shimojima, Yukinobu Tohya, Takeshi Mikami, Takayuki Miyazawa

Molecular Medicine

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Four of six specific pathogen-free cats were infected after intravaginal exposure to molecularly cloned lymphotropic but non-Crandell feline kidney (CRFK)-tropic feline immunodeficiency virus strain TM2 and its AP-1 deletion mutant. The sequences of the env V3-to-V5 region which defines the CRFK tropism were unchanged in the infected cats through the infection. These data suggest that the strain was transmitted across the mucosal epithelium without a broadening of cell tropism.

Original language	English (US)
Pages (from-to)	185-188
Number of pages	4
Journal	Clinical and Diagnostic Laboratory Immunology
Volume	10
Issue number	1
DOIs	https://doi.org/10.1128/CDLI.10.1.185-188.2003
State	Published - Jan 2003

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Clinical Biochemistry
Microbiology (medical)

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10.1128/CDLI.10.1.185-188.2003

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T1 - Experimental mucosal infection with molecularly cloned feline immunodeficiency viruses

AU - Kohmoto, Mariko

AU - Ikeda, Yasuhiro

AU - Sato, Eiji

AU - Nishimura, Yorihiro

AU - Inoshima, Yasuo

AU - Shimojima, Masayuki

AU - Tohya, Yukinobu

AU - Mikami, Takeshi

AU - Miyazawa, Takayuki

PY - 2003/1

Y1 - 2003/1

N2 - Four of six specific pathogen-free cats were infected after intravaginal exposure to molecularly cloned lymphotropic but non-Crandell feline kidney (CRFK)-tropic feline immunodeficiency virus strain TM2 and its AP-1 deletion mutant. The sequences of the env V3-to-V5 region which defines the CRFK tropism were unchanged in the infected cats through the infection. These data suggest that the strain was transmitted across the mucosal epithelium without a broadening of cell tropism.

AB - Four of six specific pathogen-free cats were infected after intravaginal exposure to molecularly cloned lymphotropic but non-Crandell feline kidney (CRFK)-tropic feline immunodeficiency virus strain TM2 and its AP-1 deletion mutant. The sequences of the env V3-to-V5 region which defines the CRFK tropism were unchanged in the infected cats through the infection. These data suggest that the strain was transmitted across the mucosal epithelium without a broadening of cell tropism.

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Experimental mucosal infection with molecularly cloned feline immunodeficiency viruses

Abstract

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