Experimental mucosal infection with molecularly cloned feline immunodeficiency viruses

Mariko Kohmoto, Yasuhiro Ikeda, Eiji Sato, Yorihiro Nishimura, Yasuo Inoshima, Masayuki Shimojima, Yukinobu Tohya, Takeshi Mikami, Takayuki Miyazawa

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Four of six specific pathogen-free cats were infected after intravaginal exposure to molecularly cloned lymphotropic but non-Crandell feline kidney (CRFK)-tropic feline immunodeficiency virus strain TM2 and its AP-1 deletion mutant. The sequences of the env V3-to-V5 region which defines the CRFK tropism were unchanged in the infected cats through the infection. These data suggest that the strain was transmitted across the mucosal epithelium without a broadening of cell tropism.

Original languageEnglish (US)
Pages (from-to)185-188
Number of pages4
JournalClinical and Diagnostic Laboratory Immunology
Volume10
Issue number1
DOIs
StatePublished - Jan 2003

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Clinical Biochemistry
  • Microbiology (medical)

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