Experimental Models of Virus-Induced Demyelination

A. J. Bieber, M. Rodriguez

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)

Abstract

This chapter reviews two of the most widely studied animal models of virus-induced demyelinating disease. These are Theiler's murine encephalomyelitis virus and murine hepatitis virus. Both viruses produce acute inflammatory encephalitis that is followed by chronic central-nervous-system (CNS) demyelinating disease. The clinical and pathologic correlates of virus-induced demyelination are largely immune mediated. Furthermore, several pathologic mechanisms have been proposed to explain the development of myelin damage and neurologic deficits, and each of the proposed mechanisms may play a role in disease progression depending on the genetic constitution of the infected animal. The induction of demyelinating disease by virus may be directly relevant to human MS. Several viruses are known to cause demyelination in humans and viral infection is an epidemiologic factor that is consistently associated with clinical exacerbation of MS. It is suggested that viral infection may be a cause of MS, although no specific virus has been identified as a causative agent.

Original languageEnglish (US)
Title of host publicationMyelin Biology and Disorders
PublisherElsevier Inc.
Pages1073-1100
Number of pages28
Volume2
ISBN (Print)9780124395107
DOIs
StatePublished - Dec 2003

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Demyelinating Diseases
Viruses
Theoretical Models
Virus Diseases
Epidemiologic Factors
Theilovirus
Murine hepatitis virus
Animals
Central Nervous System Diseases
Constitution and Bylaws
Encephalitis
Myelin Sheath
Neurologic Manifestations
Disease Progression
Neurology
Animal Models

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Bieber, A. J., & Rodriguez, M. (2003). Experimental Models of Virus-Induced Demyelination. In Myelin Biology and Disorders (Vol. 2, pp. 1073-1100). Elsevier Inc.. https://doi.org/10.1016/B978-012439510-7/50097-8

Experimental Models of Virus-Induced Demyelination. / Bieber, A. J.; Rodriguez, M.

Myelin Biology and Disorders. Vol. 2 Elsevier Inc., 2003. p. 1073-1100.

Research output: Chapter in Book/Report/Conference proceedingChapter

Bieber, AJ & Rodriguez, M 2003, Experimental Models of Virus-Induced Demyelination. in Myelin Biology and Disorders. vol. 2, Elsevier Inc., pp. 1073-1100. https://doi.org/10.1016/B978-012439510-7/50097-8
Bieber AJ, Rodriguez M. Experimental Models of Virus-Induced Demyelination. In Myelin Biology and Disorders. Vol. 2. Elsevier Inc. 2003. p. 1073-1100 https://doi.org/10.1016/B978-012439510-7/50097-8
Bieber, A. J. ; Rodriguez, M. / Experimental Models of Virus-Induced Demyelination. Myelin Biology and Disorders. Vol. 2 Elsevier Inc., 2003. pp. 1073-1100
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