Experimental models of lupus nephritis

Research output: Chapter in Book/Report/Conference proceedingChapter

13 Citations (Scopus)

Abstract

A number of murine models recapitulate many of the features of systemic lupus. Spontaneous models of lupus have provided the basis for genetic linkage studies to define loci that confer an increased risk of nephritis in susceptible mice. Functional relevance of genes within susceptibility loci have been verified through the use of transgenic mice bearing targeted deletions or overexpression of candidate genes. Critical gene targets are involved in the production of autoantigens, stimulation of B cells to produce autoantibodies, stimulation of T cells to provide B cell help and cytokine-mediated damage following tissue deposition of immune complexes. In this overview, features of the commonly employed models of human lupus nephritis are reviewed. Strategies to identify candidate genes involved in the initiation and progression of lupus nephritis in these models are discussed. Finally, key studies to validate target genes as pathophysiologically relevant mediators of lupus nephritis and studies to identify potential targets for therapeutic intervention are summarized.

Original languageEnglish (US)
Title of host publicationExperimental Models for Renal Diseases: Pathogenesis and Diagnosis
PublisherS. Karger AG
Pages183-197
Number of pages15
Volume169
ISBN (Print)9783805595384, 9783805595377
DOIs
StatePublished - Jan 14 2011

Fingerprint

Lupus Nephritis
Theoretical Models
Genes
B-Lymphocytes
Bearings (structural)
Cells
Genetic Linkage
T-cells
Nephritis
Autoantigens
Antigen-Antibody Complex
Autoantibodies
Transgenic Mice
Tissue
Cytokines
T-Lymphocytes

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Grande, J. P. (2011). Experimental models of lupus nephritis. In Experimental Models for Renal Diseases: Pathogenesis and Diagnosis (Vol. 169, pp. 183-197). S. Karger AG. https://doi.org/10.1159/000319241

Experimental models of lupus nephritis. / Grande, Joseph Peter.

Experimental Models for Renal Diseases: Pathogenesis and Diagnosis. Vol. 169 S. Karger AG, 2011. p. 183-197.

Research output: Chapter in Book/Report/Conference proceedingChapter

Grande, JP 2011, Experimental models of lupus nephritis. in Experimental Models for Renal Diseases: Pathogenesis and Diagnosis. vol. 169, S. Karger AG, pp. 183-197. https://doi.org/10.1159/000319241
Grande JP. Experimental models of lupus nephritis. In Experimental Models for Renal Diseases: Pathogenesis and Diagnosis. Vol. 169. S. Karger AG. 2011. p. 183-197 https://doi.org/10.1159/000319241
Grande, Joseph Peter. / Experimental models of lupus nephritis. Experimental Models for Renal Diseases: Pathogenesis and Diagnosis. Vol. 169 S. Karger AG, 2011. pp. 183-197
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