TY - CHAP
T1 - Experimental model of aortic valve calcification to induce osteoblast differentiation
AU - Rajamannan, Nalini M.
AU - Cicek, Muzaffer
AU - Hawse, John R.
AU - Spelsberg, Thomas C.
AU - Subramaniam, Malayannan
N1 - Publisher Copyright:
© Springer-Verlag London 2014.
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Over the past 25 years, the development of an in vivo model to test for calcific aortic valve disease has been challenging. The understanding of the biology, imaging, and duration of exposure to risk factors, have been the cornerstone for defining the different stages of osteoblast differentiation. The first experimental was high cholesterol-diet rabbit model. The studies published demonstrated apoptosis [1], cell proliferation [2], and atherosclerosis [1, 3-6] along the aortic valve surface. These models all include short time diet experiments to define the early atherosclerotic findings in the valve. The next level of experimentation includes testing the diet for 6 months. This duration of diet provides the time necessary for the valve to mineralize and to calcify.
AB - Over the past 25 years, the development of an in vivo model to test for calcific aortic valve disease has been challenging. The understanding of the biology, imaging, and duration of exposure to risk factors, have been the cornerstone for defining the different stages of osteoblast differentiation. The first experimental was high cholesterol-diet rabbit model. The studies published demonstrated apoptosis [1], cell proliferation [2], and atherosclerosis [1, 3-6] along the aortic valve surface. These models all include short time diet experiments to define the early atherosclerotic findings in the valve. The next level of experimentation includes testing the diet for 6 months. This duration of diet provides the time necessary for the valve to mineralize and to calcify.
UR - http://www.scopus.com/inward/record.url?scp=84956492358&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84956492358&partnerID=8YFLogxK
U2 - 10.1007/978-1-4471-6350-3_4
DO - 10.1007/978-1-4471-6350-3_4
M3 - Chapter
AN - SCOPUS:84956492358
SN - 9781447163497
SP - 27
EP - 33
BT - Molecular Biology of Valvular Heart Disease
PB - Springer-Verlag London Ltd
ER -