Experimental autoimmune myasthenia

a model of myasthenia gravis in rats and guinea pigs

Vanda A Lennon, J. M. Lindstrom, M. E. Seybold

Research output: Contribution to journalArticle

250 Citations (Scopus)

Abstract

Immunization of animals with acetylcholine receptor (AChR) protein from the electric organs of Electrophorus electricus and Torpedo californica induces an autoimmune response to the AChR of mammalian skeletal muscle. Rats and guinea pigs develop experimental autoimmune myasthenia gravis (EAMG) after a single inoculation with small quantities of AChR and adjuvant. The incidence and severity of disease appears to depend on the dose of AChR and stability of the emulsion. EAMG is strikingly similar to myasthenia gravis (MG) of man in its clinical picture and its electrophysiological abnormalities. The presence of antibodies to syngeneic rat muscle AChR in the serum of rats with EAMG documents the existence of autoimmunity in the experimental disease. A common immunopathogenesis is suggested for both EAMG and MG.

Original languageEnglish (US)
Pages (from-to)1365-1375
Number of pages11
JournalJournal of Experimental Medicine
Volume141
Issue number6
StatePublished - 1975
Externally publishedYes

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Autoimmune Experimental Myasthenia Gravis
Myasthenia Gravis
Cholinergic Receptors
Guinea Pigs
Autoimmunity
Electrophorus
Electric Organ
Torpedo
Emulsions
Immunization
Skeletal Muscle
Muscles
Antibodies
Incidence
Serum
Proteins

ASJC Scopus subject areas

  • Immunology

Cite this

Experimental autoimmune myasthenia : a model of myasthenia gravis in rats and guinea pigs. / Lennon, Vanda A; Lindstrom, J. M.; Seybold, M. E.

In: Journal of Experimental Medicine, Vol. 141, No. 6, 1975, p. 1365-1375.

Research output: Contribution to journalArticle

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