Abstract
Induction of adjuvant arthritis was observed in rats subjected to neonatal thymectomy, but not in sham thymectomized rats. In experiments designed primarily to assess the role of thymus derived (T) lymphocytes in the pathogenesis of autoimmune encephalomyelitis (EAE), it appeared that T lymphocytes (and associated cell mediated immunity) are not solely responsible for the pathogenesis of adjuvant induced arthritis. Thus the following mechanism is suggested to explain the high incidence of arthritis in thymectomized animals. With reduced numbers of T lymphocytes, the decreased capacity to produce antibody to certain 'thymus dependent' antigens may lead to the formation of complexes of antigen and antibody with antigen in excess; such complexes are unsuitable for elimination from the circulation and furthermore are capable of mediating immune damage to tissues.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 38-40 |
| Number of pages | 3 |
| Journal | Nature |
| Volume | 244 |
| Issue number | 5410 |
| State | Published - 1973 |
| Externally published | Yes |
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Cite this
Experimental arthritis in thymectomized rats with an impaired humoral immune response. / Lennon, Vanda A; Byrd, W. J.
In: Nature, Vol. 244, No. 5410, 1973, p. 38-40.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Experimental arthritis in thymectomized rats with an impaired humoral immune response
AU - Lennon, Vanda A
AU - Byrd, W. J.
PY - 1973
Y1 - 1973
N2 - Induction of adjuvant arthritis was observed in rats subjected to neonatal thymectomy, but not in sham thymectomized rats. In experiments designed primarily to assess the role of thymus derived (T) lymphocytes in the pathogenesis of autoimmune encephalomyelitis (EAE), it appeared that T lymphocytes (and associated cell mediated immunity) are not solely responsible for the pathogenesis of adjuvant induced arthritis. Thus the following mechanism is suggested to explain the high incidence of arthritis in thymectomized animals. With reduced numbers of T lymphocytes, the decreased capacity to produce antibody to certain 'thymus dependent' antigens may lead to the formation of complexes of antigen and antibody with antigen in excess; such complexes are unsuitable for elimination from the circulation and furthermore are capable of mediating immune damage to tissues.
AB - Induction of adjuvant arthritis was observed in rats subjected to neonatal thymectomy, but not in sham thymectomized rats. In experiments designed primarily to assess the role of thymus derived (T) lymphocytes in the pathogenesis of autoimmune encephalomyelitis (EAE), it appeared that T lymphocytes (and associated cell mediated immunity) are not solely responsible for the pathogenesis of adjuvant induced arthritis. Thus the following mechanism is suggested to explain the high incidence of arthritis in thymectomized animals. With reduced numbers of T lymphocytes, the decreased capacity to produce antibody to certain 'thymus dependent' antigens may lead to the formation of complexes of antigen and antibody with antigen in excess; such complexes are unsuitable for elimination from the circulation and furthermore are capable of mediating immune damage to tissues.
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UR - http://www.scopus.com/inward/citedby.url?scp=0015916018&partnerID=8YFLogxK
M3 - Article
C2 - 4582484
AN - SCOPUS:0015916018
VL - 244
SP - 38
EP - 40
JO - Nature
JF - Nature
SN - 0028-0836
IS - 5410
ER -