Experimental allergic neuritis. Humoral and cellular immune responses to the cyanogen bromide peptides of the P2 protein

Debra J. Milek; Julie M. Cunningham; James M. Powers; Steven W. Brostoff

doi:10.1016/0165-5728(83)90015-2

Experimental allergic neuritis. Humoral and cellular immune responses to the cyanogen bromide peptides of the P2 protein

Debra J. Milek, Julie M. Cunningham, James M. Powers, Steven W. Brostoff

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Lewis rats were immunized with P2 protein and peptides CN1, CN2 and CN3. In P2 immunized rats, antibody and cellular sensitivity to the P2 protein were seen prior to the appearance of clinical signs of EAN, during disease and during recovery. CN1 immunized rats had equal or more severe clinical and histological signs of EAN but lower antibody titers than P2 immunized animals. CN-1 elicited a greater blastogenic response in both P2 and CN-1 immunized animals. CN-2 and CN-3 immunized rats showed little clinical and histological evidence of EAN and no antibody. However, lymphocytes sensitive to the immunizing antigen and the P2 protein were present.

Original language	English (US)
Pages (from-to)	105-116
Number of pages	12
Journal	Journal of neuroimmunology
Volume	4
Issue number	2
DOIs	https://doi.org/10.1016/0165-5728(83)90015-2
State	Published - Apr 1983

Keywords

Antibody
Cell-mediated immunity
Experimental allergic newritis
Lewis rat
P2 peptides
Pathogenesis

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

Access to Document

10.1016/0165-5728(83)90015-2

Cite this

@article{aef5e686bb994bab84ac3e86379dbf95,

title = "Experimental allergic neuritis. Humoral and cellular immune responses to the cyanogen bromide peptides of the P2 protein",

abstract = "Lewis rats were immunized with P2 protein and peptides CN1, CN2 and CN3. In P2 immunized rats, antibody and cellular sensitivity to the P2 protein were seen prior to the appearance of clinical signs of EAN, during disease and during recovery. CN1 immunized rats had equal or more severe clinical and histological signs of EAN but lower antibody titers than P2 immunized animals. CN-1 elicited a greater blastogenic response in both P2 and CN-1 immunized animals. CN-2 and CN-3 immunized rats showed little clinical and histological evidence of EAN and no antibody. However, lymphocytes sensitive to the immunizing antigen and the P2 protein were present.",

keywords = "Antibody, Cell-mediated immunity, Experimental allergic newritis, Lewis rat, P2 peptides, Pathogenesis",

author = "Milek, {Debra J.} and Cunningham, {Julie M.} and Powers, {James M.} and Brostoff, {Steven W.}",

note = "Funding Information: ~ work was supported in part by Grant I~S-11867 from the USPHS. * To whomreprint requests ~muid be sent at the Departmant of Nenrokqy, Medi¢~ Uaiv~tity d Ctrolimt, 171 AshleyA venue, Charleston, SC 29425, U.S.A.",

year = "1983",

month = apr,

doi = "10.1016/0165-5728(83)90015-2",

language = "English (US)",

volume = "4",

pages = "105--116",

journal = "Journal of neuroimmunology",

issn = "0165-5728",

publisher = "Elsevier",

number = "2",

}

TY - JOUR

T1 - Experimental allergic neuritis. Humoral and cellular immune responses to the cyanogen bromide peptides of the P2 protein

AU - Milek, Debra J.

AU - Cunningham, Julie M.

AU - Powers, James M.

AU - Brostoff, Steven W.

N1 - Funding Information: ~ work was supported in part by Grant I~S-11867 from the USPHS. * To whomreprint requests ~muid be sent at the Departmant of Nenrokqy, Medi¢~ Uaiv~tity d Ctrolimt, 171 AshleyA venue, Charleston, SC 29425, U.S.A.

PY - 1983/4

Y1 - 1983/4

N2 - Lewis rats were immunized with P2 protein and peptides CN1, CN2 and CN3. In P2 immunized rats, antibody and cellular sensitivity to the P2 protein were seen prior to the appearance of clinical signs of EAN, during disease and during recovery. CN1 immunized rats had equal or more severe clinical and histological signs of EAN but lower antibody titers than P2 immunized animals. CN-1 elicited a greater blastogenic response in both P2 and CN-1 immunized animals. CN-2 and CN-3 immunized rats showed little clinical and histological evidence of EAN and no antibody. However, lymphocytes sensitive to the immunizing antigen and the P2 protein were present.

AB - Lewis rats were immunized with P2 protein and peptides CN1, CN2 and CN3. In P2 immunized rats, antibody and cellular sensitivity to the P2 protein were seen prior to the appearance of clinical signs of EAN, during disease and during recovery. CN1 immunized rats had equal or more severe clinical and histological signs of EAN but lower antibody titers than P2 immunized animals. CN-1 elicited a greater blastogenic response in both P2 and CN-1 immunized animals. CN-2 and CN-3 immunized rats showed little clinical and histological evidence of EAN and no antibody. However, lymphocytes sensitive to the immunizing antigen and the P2 protein were present.

KW - Antibody

KW - Cell-mediated immunity

KW - Experimental allergic newritis

KW - Lewis rat

KW - P2 peptides

KW - Pathogenesis

UR - http://www.scopus.com/inward/record.url?scp=0020581795&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020581795&partnerID=8YFLogxK

U2 - 10.1016/0165-5728(83)90015-2

DO - 10.1016/0165-5728(83)90015-2

M3 - Article

C2 - 6187769

AN - SCOPUS:0020581795

SN - 0165-5728

VL - 4

SP - 105

EP - 116

JO - Journal of neuroimmunology

JF - Journal of neuroimmunology

IS - 2

ER -

Experimental allergic neuritis. Humoral and cellular immune responses to the cyanogen bromide peptides of the P2 protein

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this