Exogenous hormone use, reproductive history and risk of adult myeloid leukaemia

J. N. Poynter, R. Fonstad, C. K. Blair, M. Roesler, J. R. Cerhan, B. Hirsch, P. Nguyen, J. A. Ross

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Background:A hormonal aetiology is one explanation for the lower incidence of myeloid leukaemia in women compared with men.Methods:In this population-based case-control study, we evaluated associations between exogenous hormone use and reproductive history and myeloid leukaemia, overall and by disease subtype.Results:We observed a suggestive association between oral contraceptive use and acute myeloid leukaemia (odds ratio=0.55, 95% confidence interval=0.32-0.96). Hormone replacement therapy and reproductive factors were not associated with risk.Conclusion:Despite the biological plausibility for a role of oestrogen in leukaemogenesis, other aetiologic factors are likely to explain the differing incidence rates in males and females.

Original languageEnglish (US)
Pages (from-to)1895-1898
Number of pages4
JournalBritish journal of cancer
Volume109
Issue number7
DOIs
StatePublished - Oct 1 2013

Keywords

  • hormone replacement therapy
  • myeloid leukaemia
  • oral contraceptives

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Poynter, J. N., Fonstad, R., Blair, C. K., Roesler, M., Cerhan, J. R., Hirsch, B., Nguyen, P., & Ross, J. A. (2013). Exogenous hormone use, reproductive history and risk of adult myeloid leukaemia. British journal of cancer, 109(7), 1895-1898. https://doi.org/10.1038/bjc.2013.507