Exogenous hormone use, reproductive history and risk of adult myeloid leukaemia

J. N. Poynter, R. Fonstad, C. K. Blair, M. Roesler, James R Cerhan, B. Hirsch, P. Nguyen, J. A. Ross

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background:A hormonal aetiology is one explanation for the lower incidence of myeloid leukaemia in women compared with men.Methods:In this population-based case-control study, we evaluated associations between exogenous hormone use and reproductive history and myeloid leukaemia, overall and by disease subtype.Results:We observed a suggestive association between oral contraceptive use and acute myeloid leukaemia (odds ratio=0.55, 95% confidence interval=0.32-0.96). Hormone replacement therapy and reproductive factors were not associated with risk.Conclusion:Despite the biological plausibility for a role of oestrogen in leukaemogenesis, other aetiologic factors are likely to explain the differing incidence rates in males and females.

Original languageEnglish (US)
Pages (from-to)1895-1898
Number of pages4
JournalBritish Journal of Cancer
Volume109
Issue number7
DOIs
StatePublished - Oct 1 2013

Fingerprint

Reproductive History
Myeloid Leukemia
Hormones
Incidence
Hormone Replacement Therapy
Oral Contraceptives
Acute Myeloid Leukemia
Case-Control Studies
Estrogens
Odds Ratio
Confidence Intervals
Population

Keywords

  • hormone replacement therapy
  • myeloid leukaemia
  • oral contraceptives

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Poynter, J. N., Fonstad, R., Blair, C. K., Roesler, M., Cerhan, J. R., Hirsch, B., ... Ross, J. A. (2013). Exogenous hormone use, reproductive history and risk of adult myeloid leukaemia. British Journal of Cancer, 109(7), 1895-1898. https://doi.org/10.1038/bjc.2013.507

Exogenous hormone use, reproductive history and risk of adult myeloid leukaemia. / Poynter, J. N.; Fonstad, R.; Blair, C. K.; Roesler, M.; Cerhan, James R; Hirsch, B.; Nguyen, P.; Ross, J. A.

In: British Journal of Cancer, Vol. 109, No. 7, 01.10.2013, p. 1895-1898.

Research output: Contribution to journalArticle

Poynter, JN, Fonstad, R, Blair, CK, Roesler, M, Cerhan, JR, Hirsch, B, Nguyen, P & Ross, JA 2013, 'Exogenous hormone use, reproductive history and risk of adult myeloid leukaemia', British Journal of Cancer, vol. 109, no. 7, pp. 1895-1898. https://doi.org/10.1038/bjc.2013.507
Poynter, J. N. ; Fonstad, R. ; Blair, C. K. ; Roesler, M. ; Cerhan, James R ; Hirsch, B. ; Nguyen, P. ; Ross, J. A. / Exogenous hormone use, reproductive history and risk of adult myeloid leukaemia. In: British Journal of Cancer. 2013 ; Vol. 109, No. 7. pp. 1895-1898.
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