Exogenous hormone use, reproductive history and risk of adult myeloid leukaemia

J. N. Poynter; R. Fonstad; C. K. Blair; M. Roesler; J. R. Cerhan; B. Hirsch; P. Nguyen; J. A. Ross

doi:10.1038/bjc.2013.507

Exogenous hormone use, reproductive history and risk of adult myeloid leukaemia

J. N. Poynter, R. Fonstad, C. K. Blair, M. Roesler, J. R. Cerhan, B. Hirsch, P. Nguyen, J. A. Ross

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Background:A hormonal aetiology is one explanation for the lower incidence of myeloid leukaemia in women compared with men.Methods:In this population-based case-control study, we evaluated associations between exogenous hormone use and reproductive history and myeloid leukaemia, overall and by disease subtype.Results:We observed a suggestive association between oral contraceptive use and acute myeloid leukaemia (odds ratio=0.55, 95% confidence interval=0.32-0.96). Hormone replacement therapy and reproductive factors were not associated with risk.Conclusion:Despite the biological plausibility for a role of oestrogen in leukaemogenesis, other aetiologic factors are likely to explain the differing incidence rates in males and females.

Original language	English (US)
Pages (from-to)	1895-1898
Number of pages	4
Journal	British journal of cancer
Volume	109
Issue number	7
DOIs	https://doi.org/10.1038/bjc.2013.507
State	Published - Oct 1 2013

Keywords

hormone replacement therapy
myeloid leukaemia
oral contraceptives

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1038/bjc.2013.507

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title = "Exogenous hormone use, reproductive history and risk of adult myeloid leukaemia",

abstract = "Background:A hormonal aetiology is one explanation for the lower incidence of myeloid leukaemia in women compared with men.Methods:In this population-based case-control study, we evaluated associations between exogenous hormone use and reproductive history and myeloid leukaemia, overall and by disease subtype.Results:We observed a suggestive association between oral contraceptive use and acute myeloid leukaemia (odds ratio=0.55, 95% confidence interval=0.32-0.96). Hormone replacement therapy and reproductive factors were not associated with risk.Conclusion:Despite the biological plausibility for a role of oestrogen in leukaemogenesis, other aetiologic factors are likely to explain the differing incidence rates in males and females.",

keywords = "hormone replacement therapy, myeloid leukaemia, oral contraceptives",

author = "Poynter, {J. N.} and R. Fonstad and Blair, {C. K.} and M. Roesler and Cerhan, {J. R.} and B. Hirsch and P. Nguyen and Ross, {J. A.}",

note = "Funding Information: This study was supported by NIH R01 CA107143 (to JAR), K05 CA157439 (to JAR), and R25 CA047888 (to CKB).",

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doi = "10.1038/bjc.2013.507",

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AU - Poynter, J. N.

AU - Fonstad, R.

AU - Blair, C. K.

AU - Roesler, M.

AU - Cerhan, J. R.

AU - Hirsch, B.

AU - Nguyen, P.

AU - Ross, J. A.

N1 - Funding Information: This study was supported by NIH R01 CA107143 (to JAR), K05 CA157439 (to JAR), and R25 CA047888 (to CKB).

PY - 2013/10/1

Y1 - 2013/10/1

N2 - Background:A hormonal aetiology is one explanation for the lower incidence of myeloid leukaemia in women compared with men.Methods:In this population-based case-control study, we evaluated associations between exogenous hormone use and reproductive history and myeloid leukaemia, overall and by disease subtype.Results:We observed a suggestive association between oral contraceptive use and acute myeloid leukaemia (odds ratio=0.55, 95% confidence interval=0.32-0.96). Hormone replacement therapy and reproductive factors were not associated with risk.Conclusion:Despite the biological plausibility for a role of oestrogen in leukaemogenesis, other aetiologic factors are likely to explain the differing incidence rates in males and females.

AB - Background:A hormonal aetiology is one explanation for the lower incidence of myeloid leukaemia in women compared with men.Methods:In this population-based case-control study, we evaluated associations between exogenous hormone use and reproductive history and myeloid leukaemia, overall and by disease subtype.Results:We observed a suggestive association between oral contraceptive use and acute myeloid leukaemia (odds ratio=0.55, 95% confidence interval=0.32-0.96). Hormone replacement therapy and reproductive factors were not associated with risk.Conclusion:Despite the biological plausibility for a role of oestrogen in leukaemogenesis, other aetiologic factors are likely to explain the differing incidence rates in males and females.

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KW - myeloid leukaemia

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Exogenous hormone use, reproductive history and risk of adult myeloid leukaemia

Abstract

Keywords

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