Existing and emerging therapies for managing constipation and diarrhea

Adil Eddie Bharucha, Mira M. Wouters, Jan Tack

Research output: Contribution to journalReview article

10 Scopus citations

Abstract

Functional bowel disorders (i.e., constipation and diarrhea) are characterized by abdominal pain, bloating, distention, and/or bowel habit abnormalities in the absence of obvious anatomic or physiologic abnormalities on routine diagnostic tests. These symptoms are attributable to gastrointestinal sensorimotor dysfunctions resulting from peripheral and/or central mechanisms. Available drugs target the underlying bowel disturbance (i.e., constipation, diarrhea, or both), supplemented when necessary by management of pain. Osmotic and stimulant laxatives, secretagogues, and serotonin 5-HT4 receptor agonists are approved for treating constipation. Loperamide, anticholinergic agents, rifaximin, bile-acid binding agents, eluxadoline, and clonidine are used to treat diarrhea. Several exciting new compounds, some of which have been evaluated in humans, are currently under development.

Original languageEnglish (US)
Pages (from-to)158-166
Number of pages9
JournalCurrent Opinion in Pharmacology
Volume37
DOIs
StatePublished - Dec 1 2017

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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