Existence of inverted profile in chemically responsive molecular pathways in the zebrafish liver

Choong Yong Ung, Siew Hong Lam, Xun Zhang, Hu Li, Jing Ma, Louxin Zhang, Baowen Li, Zhiyuan Gong

Research output: Contribution to journalArticle

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Abstract

How a living organism maintains its healthy equilibrium in response to endless exposure of potentially harmful chemicals is an important question in current biology. By transcriptomic analysis of zebrafish livers treated by various chemicals, we defined hubs as molecular pathways that are frequently perturbed by chemicals and have high degree of functional connectivity to other pathways. Our network analysis revealed that these hubs were organized into two groups showing inverted functionality with each other. Intriguingly, the inverted activity profiles in these two groups of hubs were observed to associate only with toxicopathological states but not with physiological changes. Furthermore, these inverted profiles were also present in rat, mouse, and human under certain toxicopathological conditions. Thus, toxicopathological-associated anti-correlated profiles in hubs not only indicate their potential use in diagnosis but also development of systems-based therapeutics to modulate gene expression by chemical approach in order to rewire the deregulated activities of hubs back to normal physiology.

Original languageEnglish (US)
Article numbere27819
JournalPloS one
Volume6
Issue number11
DOIs
StatePublished - Nov 29 2011

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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