TY - JOUR
T1 - Exhaled Nitric Oxide Changes during Acclimatization to High Altitude
T2 - A Descriptive Study
AU - Summerfield, Douglas T.
AU - Coffman, Kirsten E.
AU - Taylor, Bryan J.
AU - Issa, Amine N.
AU - Johnson, Bruce D.
N1 - Publisher Copyright:
© 2018, Mary Ann Liebert, Inc., publishers.
PY - 2018/9
Y1 - 2018/9
N2 - Aims: This study describes differences in the partial pressures of exhaled nitric oxide (PeNO) between subjects fully acclimatized (ACC) to 5300 m and those who have just arrived to high altitude. Methods: PeNO was determined in eight subjects newly exposed and nonacclimatized (non-ACC) to high altitude and compared with that in nine subjects who had ACC to high altitude for 1 month. In addition, systolic pulmonary artery pressure (sPAP) and arterial oxygen saturation (SaO2) were measured in all participants. These measurements were repeated in the non-ACC group 5 and 9 days later. Results: PeNO levels on day 1 were significantly higher in the non-ACC versus ACC cohort (8.7 ± 3.5 vs. 3.9 ± 2.2 nmHg, p = 0.004). As the non-ACC group remained at altitude, PeNO levels fell and were not different when compared with those of the ACC group by day 9 (5.9 ± 2.4 vs. 3.9 ± 2.2 nmHg, p = 0.095). Higher sPAP was correlated with lower PeNO levels in all participants (R = -0.50, p = 0.043). PeNO levels were not correlated with SaO2. Conclusions: As individuals acclimatized to high altitude, PeNO levels decreased. Even after acclimatization, PeNO levels continued to play a role in pulmonary vascular tone.
AB - Aims: This study describes differences in the partial pressures of exhaled nitric oxide (PeNO) between subjects fully acclimatized (ACC) to 5300 m and those who have just arrived to high altitude. Methods: PeNO was determined in eight subjects newly exposed and nonacclimatized (non-ACC) to high altitude and compared with that in nine subjects who had ACC to high altitude for 1 month. In addition, systolic pulmonary artery pressure (sPAP) and arterial oxygen saturation (SaO2) were measured in all participants. These measurements were repeated in the non-ACC group 5 and 9 days later. Results: PeNO levels on day 1 were significantly higher in the non-ACC versus ACC cohort (8.7 ± 3.5 vs. 3.9 ± 2.2 nmHg, p = 0.004). As the non-ACC group remained at altitude, PeNO levels fell and were not different when compared with those of the ACC group by day 9 (5.9 ± 2.4 vs. 3.9 ± 2.2 nmHg, p = 0.095). Higher sPAP was correlated with lower PeNO levels in all participants (R = -0.50, p = 0.043). PeNO levels were not correlated with SaO2. Conclusions: As individuals acclimatized to high altitude, PeNO levels decreased. Even after acclimatization, PeNO levels continued to play a role in pulmonary vascular tone.
KW - acclimatization
KW - exhaled nitric oxide
KW - high altitude populations
KW - systolic pulmonary artery pressure
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U2 - 10.1089/ham.2017.0109
DO - 10.1089/ham.2017.0109
M3 - Article
C2 - 29757001
AN - SCOPUS:85053917648
SN - 1527-0297
VL - 19
SP - 215
EP - 220
JO - High Altitude Medicine and Biology
JF - High Altitude Medicine and Biology
IS - 3
ER -