Exercise Ventilatory Efficiency in Older and Younger Heart Failure Patients With Preserved Ejection Fraction

Research output: Contribution to journalArticle

Abstract

Background: Patients with heart failure with preserved ejection fraction (HFpEF) exhibit pulmonary abnormalities, but the studies to date have reported wide variability in the ventilatory equivalent for carbon dioxide (V̇ E /V̇CO 2 ) slope. It is possible that aging may contribute to that variability. We sought to compare ventilatory efficiency and its components in older and younger HFpEF patients during exercise. Methods and Results: Eighteen older (O; 80 ± 4 y) and 19 younger (Y; 59 ± 7 y) HFpEF patients performed cardiopulmonary exercise testing to volitional fatigue. Measurements of arterial blood gases were used to derive V D /V T , dead space ventilation, and alveolar ventilation. V̇ E /V̇CO 2 slope was greater in older compared with younger HFpEF patients (O 36 ± 7vs Y 31 ± 7; P =.04). At peak exercise, older HFpEF exhibited greater V D /V T compared with younger HFpEF (O 0.37 ± 0.10vs Y 0.28 ± 0.10; P <.01), whereas PaCO 2 was not different between groups (P =.58). V̇ E and alveolar ventilation were similar (P >.23), but dead space ventilation was greater in older compared with younger HFpEF at peak exercise (P =.04). Conclusions: Older HFpEF patients exhibit greater ventilatory inefficiency resulting from elevated physiologic dead space during peak exercise compared with younger HFpEF patients. These results suggest that aging can worsen the pathophysiologic mechanisms underlying ventilatory efficiency during exercise in HFpEF.

Original languageEnglish (US)
Pages (from-to)278-285
Number of pages8
JournalJournal of Cardiac Failure
Volume25
Issue number4
DOIs
StatePublished - Apr 1 2019

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Heart Failure
Exercise
Ventilation
Carbon Dioxide
Fatigue
Gases
Lung

Keywords

  • aging
  • Breathing strategy
  • hyperventilation
  • physiologic dead space

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Exercise Ventilatory Efficiency in Older and Younger Heart Failure Patients With Preserved Ejection Fraction. / Smith, Joshua R.; Borlaug, Barry A; Olson, Thomas P.

In: Journal of Cardiac Failure, Vol. 25, No. 4, 01.04.2019, p. 278-285.

Research output: Contribution to journalArticle

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