Exercise training improves endothelial function in resistance arteries of young prehypertensives

D. T. Beck; J. S. Martin; D. P. Casey; R. W. Braith

doi:10.1038/jhh.2013.109

Exercise training improves endothelial function in resistance arteries of young prehypertensives

D. T. Beck, J. S. Martin, D. P. Casey, R. W. Braith

Anesthesiology

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

Prehypertension is associated with reduced conduit artery endothelial function and perturbation of oxidant/antioxidant status. It is unknown whether endothelial dysfunction persists to resistance arteries and whether exercise training affects oxidant/antioxidant balance in young prehypertensives. We examined resistance artery function using venous occlusion plethysmography measurement of forearm (FBF) and calf blood flow (CBF) at rest and during reactive hyperaemia (RH), as well as lipid peroxidation (8-iso-PGF _2α) and antioxidant capacity (Trolox-equivalent antioxidant capacity; TEAC) before and after exercise intervention or time control. Forty-three unmedicated prehypertensive and 15 matched normotensive time controls met screening requirements and participated in the study (age: 21.1±0.8 years). Prehypertensive subjects were randomly assigned to resistance exercise training (PHRT; n=15), endurance exercise training (PHET; n=13) or time-control groups (PHTC; n=15). Treatment groups exercised 3 days per week for 8 weeks. Peak and total FBF were lower in prehypertensives than normotensives (12.7±1.2 ml min^-1 per100 ml tissue and 89.1±7.7 ml min^-1 per 100 ml tissue vs 16.3±1.0 ml min^-1 per 100 ml tissue and 123.3±6.4 ml min^-1 per 100 ml tissue, respectively; P<0.05). Peak and total CBF were lower in prehypertensives than normotensives (15.3±1.2 ml min^-1 per 100 ml tissue and 74±8.3 ml min^-1 per 100 ml tissue vs 20.9±1.4 ml min^-1 per 100 ml tissue and 107±9.2 ml min^-1 per 100 ml tissue, respectively; P<0.05). PHRT and PHET improved humoral measures of TEAC (+24 and +30%) and 8-iso-PGF _2α (-43 and -40%, respectively; P≤0.05). This study provides evidence that young prehypertensives exhibit reduced resistance artery endothelial function and that short-term (8 weeks) resistance or endurance training are effective in improving resistance artery endothelial function and oxidant/antioxidant balance in young prehypertensives.

Original language	English (US)
Pages (from-to)	303-309
Number of pages	7
Journal	Journal of Human Hypertension
Volume	28
Issue number	5
DOIs	https://doi.org/10.1038/jhh.2013.109
State	Published - May 2014

Keywords

antioxidants
endothelial function
exercise
oxidants
prehypertension
resistance arteries

ASJC Scopus subject areas

Internal Medicine

Access to Document

10.1038/jhh.2013.109

Cite this

@article{b91c81609aea40dabf1cd6703a201de9,

title = "Exercise training improves endothelial function in resistance arteries of young prehypertensives",

abstract = "Prehypertension is associated with reduced conduit artery endothelial function and perturbation of oxidant/antioxidant status. It is unknown whether endothelial dysfunction persists to resistance arteries and whether exercise training affects oxidant/antioxidant balance in young prehypertensives. We examined resistance artery function using venous occlusion plethysmography measurement of forearm (FBF) and calf blood flow (CBF) at rest and during reactive hyperaemia (RH), as well as lipid peroxidation (8-iso-PGF 2α) and antioxidant capacity (Trolox-equivalent antioxidant capacity; TEAC) before and after exercise intervention or time control. Forty-three unmedicated prehypertensive and 15 matched normotensive time controls met screening requirements and participated in the study (age: 21.1±0.8 years). Prehypertensive subjects were randomly assigned to resistance exercise training (PHRT; n=15), endurance exercise training (PHET; n=13) or time-control groups (PHTC; n=15). Treatment groups exercised 3 days per week for 8 weeks. Peak and total FBF were lower in prehypertensives than normotensives (12.7±1.2 ml min-1 per100 ml tissue and 89.1±7.7 ml min-1 per 100 ml tissue vs 16.3±1.0 ml min-1 per 100 ml tissue and 123.3±6.4 ml min-1 per 100 ml tissue, respectively; P<0.05). Peak and total CBF were lower in prehypertensives than normotensives (15.3±1.2 ml min-1 per 100 ml tissue and 74±8.3 ml min-1 per 100 ml tissue vs 20.9±1.4 ml min-1 per 100 ml tissue and 107±9.2 ml min-1 per 100 ml tissue, respectively; P<0.05). PHRT and PHET improved humoral measures of TEAC (+24 and +30%) and 8-iso-PGF 2α (-43 and -40%, respectively; P≤0.05). This study provides evidence that young prehypertensives exhibit reduced resistance artery endothelial function and that short-term (8 weeks) resistance or endurance training are effective in improving resistance artery endothelial function and oxidant/antioxidant balance in young prehypertensives.",

keywords = "antioxidants, endothelial function, exercise, oxidants, prehypertension, resistance arteries",

author = "Beck, {D. T.} and Martin, {J. S.} and Casey, {D. P.} and Braith, {R. W.}",

note = "Funding Information: All authors participated in the design and interpretation of the study and review of the manuscript. DTB, JSM and DPC conducted the experiments and analyzed the data. DTB, DPC and JSM trained the subjects, supervised the trainers and collected data for the study. DTB, RWB, DPC and JSM wrote and revised the manuscript. The authors also thank their subjects for their time and effort. This work was supported, in part, by a National Institutes of Health predoctoral training grant (NIH 5-T32-HL083810-04) awarded by the University of Florida Hypertension Center.",

year = "2014",

month = may,

doi = "10.1038/jhh.2013.109",

language = "English (US)",

volume = "28",

pages = "303--309",

journal = "Journal of Human Hypertension",

issn = "0950-9240",

publisher = "Nature Publishing Group",

number = "5",

}

TY - JOUR

T1 - Exercise training improves endothelial function in resistance arteries of young prehypertensives

AU - Beck, D. T.

AU - Martin, J. S.

AU - Casey, D. P.

AU - Braith, R. W.

N1 - Funding Information: All authors participated in the design and interpretation of the study and review of the manuscript. DTB, JSM and DPC conducted the experiments and analyzed the data. DTB, DPC and JSM trained the subjects, supervised the trainers and collected data for the study. DTB, RWB, DPC and JSM wrote and revised the manuscript. The authors also thank their subjects for their time and effort. This work was supported, in part, by a National Institutes of Health predoctoral training grant (NIH 5-T32-HL083810-04) awarded by the University of Florida Hypertension Center.

PY - 2014/5

Y1 - 2014/5

N2 - Prehypertension is associated with reduced conduit artery endothelial function and perturbation of oxidant/antioxidant status. It is unknown whether endothelial dysfunction persists to resistance arteries and whether exercise training affects oxidant/antioxidant balance in young prehypertensives. We examined resistance artery function using venous occlusion plethysmography measurement of forearm (FBF) and calf blood flow (CBF) at rest and during reactive hyperaemia (RH), as well as lipid peroxidation (8-iso-PGF 2α) and antioxidant capacity (Trolox-equivalent antioxidant capacity; TEAC) before and after exercise intervention or time control. Forty-three unmedicated prehypertensive and 15 matched normotensive time controls met screening requirements and participated in the study (age: 21.1±0.8 years). Prehypertensive subjects were randomly assigned to resistance exercise training (PHRT; n=15), endurance exercise training (PHET; n=13) or time-control groups (PHTC; n=15). Treatment groups exercised 3 days per week for 8 weeks. Peak and total FBF were lower in prehypertensives than normotensives (12.7±1.2 ml min-1 per100 ml tissue and 89.1±7.7 ml min-1 per 100 ml tissue vs 16.3±1.0 ml min-1 per 100 ml tissue and 123.3±6.4 ml min-1 per 100 ml tissue, respectively; P<0.05). Peak and total CBF were lower in prehypertensives than normotensives (15.3±1.2 ml min-1 per 100 ml tissue and 74±8.3 ml min-1 per 100 ml tissue vs 20.9±1.4 ml min-1 per 100 ml tissue and 107±9.2 ml min-1 per 100 ml tissue, respectively; P<0.05). PHRT and PHET improved humoral measures of TEAC (+24 and +30%) and 8-iso-PGF 2α (-43 and -40%, respectively; P≤0.05). This study provides evidence that young prehypertensives exhibit reduced resistance artery endothelial function and that short-term (8 weeks) resistance or endurance training are effective in improving resistance artery endothelial function and oxidant/antioxidant balance in young prehypertensives.

AB - Prehypertension is associated with reduced conduit artery endothelial function and perturbation of oxidant/antioxidant status. It is unknown whether endothelial dysfunction persists to resistance arteries and whether exercise training affects oxidant/antioxidant balance in young prehypertensives. We examined resistance artery function using venous occlusion plethysmography measurement of forearm (FBF) and calf blood flow (CBF) at rest and during reactive hyperaemia (RH), as well as lipid peroxidation (8-iso-PGF 2α) and antioxidant capacity (Trolox-equivalent antioxidant capacity; TEAC) before and after exercise intervention or time control. Forty-three unmedicated prehypertensive and 15 matched normotensive time controls met screening requirements and participated in the study (age: 21.1±0.8 years). Prehypertensive subjects were randomly assigned to resistance exercise training (PHRT; n=15), endurance exercise training (PHET; n=13) or time-control groups (PHTC; n=15). Treatment groups exercised 3 days per week for 8 weeks. Peak and total FBF were lower in prehypertensives than normotensives (12.7±1.2 ml min-1 per100 ml tissue and 89.1±7.7 ml min-1 per 100 ml tissue vs 16.3±1.0 ml min-1 per 100 ml tissue and 123.3±6.4 ml min-1 per 100 ml tissue, respectively; P<0.05). Peak and total CBF were lower in prehypertensives than normotensives (15.3±1.2 ml min-1 per 100 ml tissue and 74±8.3 ml min-1 per 100 ml tissue vs 20.9±1.4 ml min-1 per 100 ml tissue and 107±9.2 ml min-1 per 100 ml tissue, respectively; P<0.05). PHRT and PHET improved humoral measures of TEAC (+24 and +30%) and 8-iso-PGF 2α (-43 and -40%, respectively; P≤0.05). This study provides evidence that young prehypertensives exhibit reduced resistance artery endothelial function and that short-term (8 weeks) resistance or endurance training are effective in improving resistance artery endothelial function and oxidant/antioxidant balance in young prehypertensives.

KW - antioxidants

KW - endothelial function

KW - exercise

KW - oxidants

KW - prehypertension

KW - resistance arteries

UR - http://www.scopus.com/inward/record.url?scp=84898548948&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84898548948&partnerID=8YFLogxK

U2 - 10.1038/jhh.2013.109

DO - 10.1038/jhh.2013.109

M3 - Article

C2 - 24172292

AN - SCOPUS:84898548948

SN - 0950-9240

VL - 28

SP - 303

EP - 309

JO - Journal of Human Hypertension

JF - Journal of Human Hypertension

IS - 5

ER -

Exercise training improves endothelial function in resistance arteries of young prehypertensives

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this