TY - JOUR
T1 - Exercise-related change in airway blood flow in humans
T2 - Relationship to changes in cardiac output and ventilation
AU - Morris, Norman R.
AU - Ceridon, Maile L.
AU - Beck, Kenneth C.
AU - Strom, Nicholas A.
AU - Schneider, Donald A.
AU - Mendes, Eliana S.
AU - Wanner, Adam
AU - Johnson, Bruce D.
N1 - Funding Information:
The authors of this study would like to thank Kathy O’Malley for her assistance in the data collection and management of this project. This work was supported in part by National Institute of Health grant HL71478 and Griffith University.
PY - 2008/8/31
Y1 - 2008/8/31
N2 - This study examined the relationship between airway blood flow (over(Q, ̇)aw), ventilation (over(V, ̇)E) and cardiac output (over(Q, ̇)tot) during exercise in healthy humans (n = 12, mean age 34 ± 11 yr). over(Q, ̇)aw was estimated from the uptake of the soluble gas dimethyl ether while over(V, ̇)E and over(Q, ̇)tot were measured using open circuit spirometry. Measurements were made prior to and during exercise at 34 ± 5 W (Load 1) and 68 ± 10 W (Load 2) and following the cessation of exercise (recovery). over(Q, ̇)aw increased in a stepwise fashion (P < 0.05) from rest (52.8 ± 19.5 μl min-1 ml-1) to exercise at Load 1 (67.0 ± 20.3 μl min-1 ml-1) and Load 2 (84.0 ± 22.9 μl min-1 ml-1) before returning to pre-exercise levels in recovery (51.7 ± 13.2 μl min-1 ml-1). over(Q, ̇)aw was positively correlated with both over(Q, ̇)tot (r = 0.58, P < 0.01) and over(V, ̇)E (r = 0.50, P < 0.01). These results demonstrate that the increase in over(Q, ̇)aw is linked to an exercise related increase in both over(Q, ̇)tot and over(V, ̇)E and may be necessary to prevent excessive airway cooling and drying.
AB - This study examined the relationship between airway blood flow (over(Q, ̇)aw), ventilation (over(V, ̇)E) and cardiac output (over(Q, ̇)tot) during exercise in healthy humans (n = 12, mean age 34 ± 11 yr). over(Q, ̇)aw was estimated from the uptake of the soluble gas dimethyl ether while over(V, ̇)E and over(Q, ̇)tot were measured using open circuit spirometry. Measurements were made prior to and during exercise at 34 ± 5 W (Load 1) and 68 ± 10 W (Load 2) and following the cessation of exercise (recovery). over(Q, ̇)aw increased in a stepwise fashion (P < 0.05) from rest (52.8 ± 19.5 μl min-1 ml-1) to exercise at Load 1 (67.0 ± 20.3 μl min-1 ml-1) and Load 2 (84.0 ± 22.9 μl min-1 ml-1) before returning to pre-exercise levels in recovery (51.7 ± 13.2 μl min-1 ml-1). over(Q, ̇)aw was positively correlated with both over(Q, ̇)tot (r = 0.58, P < 0.01) and over(V, ̇)E (r = 0.50, P < 0.01). These results demonstrate that the increase in over(Q, ̇)aw is linked to an exercise related increase in both over(Q, ̇)tot and over(V, ̇)E and may be necessary to prevent excessive airway cooling and drying.
KW - Bronchial blood flow
KW - Cardiac output
KW - Ventilation
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U2 - 10.1016/j.resp.2008.06.020
DO - 10.1016/j.resp.2008.06.020
M3 - Article
C2 - 18647664
AN - SCOPUS:50849103017
SN - 1569-9048
VL - 162
SP - 204
EP - 209
JO - Respiratory Physiology and Neurobiology
JF - Respiratory Physiology and Neurobiology
IS - 3
ER -