TY - JOUR
T1 - Exercise-induced changes in ocular blood flow parameters in primary open-Angle glaucoma patients
AU - Gracitelli, Carolina P.B.
AU - De Faria, Nubia Vanessa Lima
AU - Almeida, Izabela
AU - Dias, Diego Torres
AU - Vieira, Julia Maggi
AU - Dorairaj, Syril
AU - Kanadani, Fabio Nishimura
AU - Prata, Tiago Santos
N1 - Publisher Copyright:
© 2019 S. Karger AG, Basel.
PY - 2020/5/1
Y1 - 2020/5/1
N2 - Purpose: To evaluate exercise-induced changes in ocular blood flow (OBF) parameters in primary open-Angle glaucoma (POAG) patients. Methods: A prospective observational study was carried out, in which medically treated patients with POAG were enrolled. Following inclusion, all patients performed a 40-min cycloergometry in a standardized fashion. The following parameters were measured and compared immediately before and 1 and 30 min after the exercise: intraocular pressure (IOP; Goldman applanation tonometry), mean arterial pressure (MAP), ocular pulse amplitude (OPA; assessed by dynamic contour tonometry), and ocular perfusion pressure (OPP; 2/3 MAP - IOP). In addition, we investigated possible factors associated with OBF parameter changes immediately after exercise. Results: A total of 30 eyes (30 patients; mean age was 62.9 ± 1.7 years) were included. Most patients were women (53%), and median visual field mean deviation index was -3.5 dB. Both MAP (mean change, 21%) and IOP (mean change, 17.3%) increased significantly immediately after the workout (p < 0.01), persisting higher than baseline following 30 min (p < 0.01%). Regarding OBF parameters, both OPA (mean change, 58.8%) and OPP (mean change, 21.7%) increased significantly immediately after the workout and persisted higher than baseline 30 min after the workout (p < 0.01). Regression analysis revealed that only age was significantly associated with OPA variation (R2 0.14; p < 0.05). No significant associations were found for OPP (p ≥ 0.19). Conclusion: Aerobic exercise leads to a significant short-Time increase in OBF parameters in patients with POAG. Even though IOP seems to present a modest elevation, it is accompanied by a significant increase in MAP, leading to higher OBF measurements. Exercise-induced short-Term changes and its possible implications for glaucoma prognosis deserve further investigation.
AB - Purpose: To evaluate exercise-induced changes in ocular blood flow (OBF) parameters in primary open-Angle glaucoma (POAG) patients. Methods: A prospective observational study was carried out, in which medically treated patients with POAG were enrolled. Following inclusion, all patients performed a 40-min cycloergometry in a standardized fashion. The following parameters were measured and compared immediately before and 1 and 30 min after the exercise: intraocular pressure (IOP; Goldman applanation tonometry), mean arterial pressure (MAP), ocular pulse amplitude (OPA; assessed by dynamic contour tonometry), and ocular perfusion pressure (OPP; 2/3 MAP - IOP). In addition, we investigated possible factors associated with OBF parameter changes immediately after exercise. Results: A total of 30 eyes (30 patients; mean age was 62.9 ± 1.7 years) were included. Most patients were women (53%), and median visual field mean deviation index was -3.5 dB. Both MAP (mean change, 21%) and IOP (mean change, 17.3%) increased significantly immediately after the workout (p < 0.01), persisting higher than baseline following 30 min (p < 0.01%). Regarding OBF parameters, both OPA (mean change, 58.8%) and OPP (mean change, 21.7%) increased significantly immediately after the workout and persisted higher than baseline 30 min after the workout (p < 0.01). Regression analysis revealed that only age was significantly associated with OPA variation (R2 0.14; p < 0.05). No significant associations were found for OPP (p ≥ 0.19). Conclusion: Aerobic exercise leads to a significant short-Time increase in OBF parameters in patients with POAG. Even though IOP seems to present a modest elevation, it is accompanied by a significant increase in MAP, leading to higher OBF measurements. Exercise-induced short-Term changes and its possible implications for glaucoma prognosis deserve further investigation.
KW - Exercise
KW - Glaucoma
KW - Intraocular pressure
KW - Ocular blood flow
KW - Ocular perfusion pressure
KW - Ocular pulse amplitude
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U2 - 10.1159/000501694
DO - 10.1159/000501694
M3 - Article
C2 - 31484192
AN - SCOPUS:85072110582
SN - 0030-3747
VL - 63
SP - 309
EP - 313
JO - Ophthalmic Research
JF - Ophthalmic Research
IS - 3
ER -