Exercise-induced changes in ocular blood flow parameters in primary open-Angle glaucoma patients

Carolina P.B. Gracitelli, Nubia Vanessa Lima De Faria, Izabela Almeida, Diego Torres Dias, Julia Maggi Vieira, Syril Dorairaj, Fabio Nishimura Kanadani, Tiago Santos Prata

Research output: Contribution to journalArticle

Abstract

Purpose: To evaluate exercise-induced changes in ocular blood flow (OBF) parameters in primary open-Angle glaucoma (POAG) patients. Methods: A prospective observational study was carried out, in which medically treated patients with POAG were enrolled. Following inclusion, all patients performed a 40-min cycloergometry in a standardized fashion. The following parameters were measured and compared immediately before and 1 and 30 min after the exercise: intraocular pressure (IOP; Goldman applanation tonometry), mean arterial pressure (MAP), ocular pulse amplitude (OPA; assessed by dynamic contour tonometry), and ocular perfusion pressure (OPP; 2/3 MAP - IOP). In addition, we investigated possible factors associated with OBF parameter changes immediately after exercise. Results: A total of 30 eyes (30 patients; mean age was 62.9 ± 1.7 years) were included. Most patients were women (53%), and median visual field mean deviation index was -3.5 dB. Both MAP (mean change, 21%) and IOP (mean change, 17.3%) increased significantly immediately after the workout (p < 0.01), persisting higher than baseline following 30 min (p < 0.01%). Regarding OBF parameters, both OPA (mean change, 58.8%) and OPP (mean change, 21.7%) increased significantly immediately after the workout and persisted higher than baseline 30 min after the workout (p < 0.01). Regression analysis revealed that only age was significantly associated with OPA variation (R2 0.14; p < 0.05). No significant associations were found for OPP (p ≥ 0.19). Conclusion: Aerobic exercise leads to a significant short-Time increase in OBF parameters in patients with POAG. Even though IOP seems to present a modest elevation, it is accompanied by a significant increase in MAP, leading to higher OBF measurements. Exercise-induced short-Term changes and its possible implications for glaucoma prognosis deserve further investigation.

Original languageEnglish (US)
Pages (from-to)309-313
Number of pages5
JournalOphthalmic Research
Volume63
Issue number3
DOIs
StatePublished - May 1 2020

Keywords

  • Exercise
  • Glaucoma
  • Intraocular pressure
  • Ocular blood flow
  • Ocular perfusion pressure
  • Ocular pulse amplitude

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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  • Cite this

    Gracitelli, C. P. B., De Faria, N. V. L., Almeida, I., Dias, D. T., Vieira, J. M., Dorairaj, S., Kanadani, F. N., & Prata, T. S. (2020). Exercise-induced changes in ocular blood flow parameters in primary open-Angle glaucoma patients. Ophthalmic Research, 63(3), 309-313. https://doi.org/10.1159/000501694