Exercise Capacity, Breathing Pattern, and Gas Exchange During Exercise for Patients with Isolated Diastolic Dysfunction

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Abstract

Background: Left ventricular diastolic dysfunction (DiaD) is as common as left ventricular systolic dysfunction. Whether these causes of heart failure lead to similar breathing pattern and gas exchange responses to exercise remains unclear. Methods: Participants (control subjects [n = 47], systolic dysfunction [n = 46], and DiaD [n = 40]) underwent resting echocardiograms and cardiopulmonary exercise testing. Results: Patients demonstrated lower peak oxygen consumption and tidal volume than control subjects (P < .05). Ventilation tended to be highest in DiaD. The submaximal ventilatory equivalent for carbon dioxide was highest in DiaD. Left atrial volume (all groups) was correlated with peak oxygen consumption (r = -0.38) whereas the ratio of early mitral inflow velocity to early mitral annular velocity was related to peak oxygen consumption (r = -0.36) and treadmill time (r = -0.35). Conclusion: Isolated DiaD is associated with altered breathing pattern and gas exchange similar to systolic dysfunction. Elevated left atrial volume, higher early mitral inflow velocity to early mitral annular velocity ratio, or both are predictive of exercise capacity and elevated ventilatory responses in patients with DiaD suggesting a role for dysfunctional ventricular relaxation.

Original languageEnglish (US)
Pages (from-to)838-846
Number of pages9
JournalJournal of the American Society of Echocardiography
Volume20
Issue number7
DOIs
StatePublished - Jul 2007

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Breathing Exercises
Oxygen Consumption
Gases
Left Ventricular Dysfunction
Exercise
Respiration
Tidal Volume
Carbon Dioxide
Ventilation
Heart Failure

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

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title = "Exercise Capacity, Breathing Pattern, and Gas Exchange During Exercise for Patients with Isolated Diastolic Dysfunction",
abstract = "Background: Left ventricular diastolic dysfunction (DiaD) is as common as left ventricular systolic dysfunction. Whether these causes of heart failure lead to similar breathing pattern and gas exchange responses to exercise remains unclear. Methods: Participants (control subjects [n = 47], systolic dysfunction [n = 46], and DiaD [n = 40]) underwent resting echocardiograms and cardiopulmonary exercise testing. Results: Patients demonstrated lower peak oxygen consumption and tidal volume than control subjects (P < .05). Ventilation tended to be highest in DiaD. The submaximal ventilatory equivalent for carbon dioxide was highest in DiaD. Left atrial volume (all groups) was correlated with peak oxygen consumption (r = -0.38) whereas the ratio of early mitral inflow velocity to early mitral annular velocity was related to peak oxygen consumption (r = -0.36) and treadmill time (r = -0.35). Conclusion: Isolated DiaD is associated with altered breathing pattern and gas exchange similar to systolic dysfunction. Elevated left atrial volume, higher early mitral inflow velocity to early mitral annular velocity ratio, or both are predictive of exercise capacity and elevated ventilatory responses in patients with DiaD suggesting a role for dysfunctional ventricular relaxation.",
author = "Arruda, {Ana Lucia M} and Patricia Pellikka and Olson, {Thomas P} and Johnson, {Bruce David}",
year = "2007",
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T1 - Exercise Capacity, Breathing Pattern, and Gas Exchange During Exercise for Patients with Isolated Diastolic Dysfunction

AU - Arruda, Ana Lucia M

AU - Pellikka, Patricia

AU - Olson, Thomas P

AU - Johnson, Bruce David

PY - 2007/7

Y1 - 2007/7

N2 - Background: Left ventricular diastolic dysfunction (DiaD) is as common as left ventricular systolic dysfunction. Whether these causes of heart failure lead to similar breathing pattern and gas exchange responses to exercise remains unclear. Methods: Participants (control subjects [n = 47], systolic dysfunction [n = 46], and DiaD [n = 40]) underwent resting echocardiograms and cardiopulmonary exercise testing. Results: Patients demonstrated lower peak oxygen consumption and tidal volume than control subjects (P < .05). Ventilation tended to be highest in DiaD. The submaximal ventilatory equivalent for carbon dioxide was highest in DiaD. Left atrial volume (all groups) was correlated with peak oxygen consumption (r = -0.38) whereas the ratio of early mitral inflow velocity to early mitral annular velocity was related to peak oxygen consumption (r = -0.36) and treadmill time (r = -0.35). Conclusion: Isolated DiaD is associated with altered breathing pattern and gas exchange similar to systolic dysfunction. Elevated left atrial volume, higher early mitral inflow velocity to early mitral annular velocity ratio, or both are predictive of exercise capacity and elevated ventilatory responses in patients with DiaD suggesting a role for dysfunctional ventricular relaxation.

AB - Background: Left ventricular diastolic dysfunction (DiaD) is as common as left ventricular systolic dysfunction. Whether these causes of heart failure lead to similar breathing pattern and gas exchange responses to exercise remains unclear. Methods: Participants (control subjects [n = 47], systolic dysfunction [n = 46], and DiaD [n = 40]) underwent resting echocardiograms and cardiopulmonary exercise testing. Results: Patients demonstrated lower peak oxygen consumption and tidal volume than control subjects (P < .05). Ventilation tended to be highest in DiaD. The submaximal ventilatory equivalent for carbon dioxide was highest in DiaD. Left atrial volume (all groups) was correlated with peak oxygen consumption (r = -0.38) whereas the ratio of early mitral inflow velocity to early mitral annular velocity was related to peak oxygen consumption (r = -0.36) and treadmill time (r = -0.35). Conclusion: Isolated DiaD is associated with altered breathing pattern and gas exchange similar to systolic dysfunction. Elevated left atrial volume, higher early mitral inflow velocity to early mitral annular velocity ratio, or both are predictive of exercise capacity and elevated ventilatory responses in patients with DiaD suggesting a role for dysfunctional ventricular relaxation.

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