Executive dysfunction is the primary cognitive impairment in progressive supranuclear palsy

Adam Gerstenecker, Benjamin Mast, Kevin Duff, Tanis Jill Ferman, Irene Litvan

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Cognitive difficulties appear to be a more prevalent clinical feature in progressive supranuclear palsy (PSP) than previously thought, and significant cognitive impairment is prevalent in a majority of patients PSP patients not considered clinically demented. The neurocognitive performance of 200 patients with PSP across multiple sites was examined with a variety of commonly used neuropsychological tests. Results indicate primary executive dysfunction (e.g., 74% impaired on the Frontal Assessment Battery, 55% impaired on Initiation/Perseveration subscale of the Dementia Rating Scale), with milder difficulties in memory, construction, and naming. These results have important clinical implications for providers following patients with PSP.

Original languageEnglish (US)
Pages (from-to)104-113
Number of pages10
JournalArchives of Clinical Neuropsychology
Volume28
Issue number2
DOIs
StatePublished - Mar 2013

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Progressive Supranuclear Palsy
Neuropsychological Tests
Dementia
Cognitive Dysfunction

Keywords

  • Dementia
  • Frontal-executive
  • Memory
  • Parkinsonism
  • Progressive supranuclear palsy

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology
  • Neuropsychology and Physiological Psychology

Cite this

Executive dysfunction is the primary cognitive impairment in progressive supranuclear palsy. / Gerstenecker, Adam; Mast, Benjamin; Duff, Kevin; Ferman, Tanis Jill; Litvan, Irene.

In: Archives of Clinical Neuropsychology, Vol. 28, No. 2, 03.2013, p. 104-113.

Research output: Contribution to journalArticle

Gerstenecker, Adam ; Mast, Benjamin ; Duff, Kevin ; Ferman, Tanis Jill ; Litvan, Irene. / Executive dysfunction is the primary cognitive impairment in progressive supranuclear palsy. In: Archives of Clinical Neuropsychology. 2013 ; Vol. 28, No. 2. pp. 104-113.
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