Executive dysfunction is the primary cognitive impairment in progressive supranuclear palsy

Adam Gerstenecker, Benjamin Mast, Kevin Duff, Tanis J. Ferman, Irene Litvan

Research output: Contribution to journalArticle

46 Scopus citations

Abstract

Cognitive difficulties appear to be a more prevalent clinical feature in progressive supranuclear palsy (PSP) than previously thought, and significant cognitive impairment is prevalent in a majority of patients PSP patients not considered clinically demented. The neurocognitive performance of 200 patients with PSP across multiple sites was examined with a variety of commonly used neuropsychological tests. Results indicate primary executive dysfunction (e.g., 74% impaired on the Frontal Assessment Battery, 55% impaired on Initiation/Perseveration subscale of the Dementia Rating Scale), with milder difficulties in memory, construction, and naming. These results have important clinical implications for providers following patients with PSP.

Original languageEnglish (US)
Pages (from-to)104-113
Number of pages10
JournalArchives of Clinical Neuropsychology
Volume28
Issue number2
DOIs
StatePublished - Mar 2013

Keywords

  • Dementia
  • Frontal-executive
  • Memory
  • Parkinsonism
  • Progressive supranuclear palsy

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Clinical Psychology
  • Psychiatry and Mental health

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