TY - JOUR
T1 - Executive control function
T2 - A review of its promise and challenges for clinical research - A report from the Committee on Research of the American Neuropsychiatric Association
AU - Royall, Donald R.
AU - Lauterbach, Edward C.
AU - Cummings, Jeffrey L.
AU - Reeve, Allison
AU - Rummans, Teresa A.
AU - Kaufer, Daniel I.
AU - LaFrance, W. Curt
AU - Coffey, C. Edward
PY - 2002/9
Y1 - 2002/9
N2 - This report reviews the state of the literature and opportunities for research related to "executive control function" (ECF). ECF has recently been separated from the specific cognitive domains (memory, language, and praxis) traditionally used to assess patients. ECF impairment has been associated with lesions to the frontal cortex and its basal ganglia-thalamic connections. No single putative ECF measure can yet serve as a "gold standard." This and other obstacles to assessment of ECF are reviewed. ECF impairment and related frontal system lesions and metabolic disturbances have been detected in many psychiatric and medical disorders and are strongly associated with functional outcomes, disability, and specific problem behaviors. The prevalence and severity of ECF deficits in many disorders remain to be determined, and treatment has been attempted in only a few disorders. Much more research in these areas is necessary.
AB - This report reviews the state of the literature and opportunities for research related to "executive control function" (ECF). ECF has recently been separated from the specific cognitive domains (memory, language, and praxis) traditionally used to assess patients. ECF impairment has been associated with lesions to the frontal cortex and its basal ganglia-thalamic connections. No single putative ECF measure can yet serve as a "gold standard." This and other obstacles to assessment of ECF are reviewed. ECF impairment and related frontal system lesions and metabolic disturbances have been detected in many psychiatric and medical disorders and are strongly associated with functional outcomes, disability, and specific problem behaviors. The prevalence and severity of ECF deficits in many disorders remain to be determined, and treatment has been attempted in only a few disorders. Much more research in these areas is necessary.
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U2 - 10.1176/appi.neuropsych.14.4.377
DO - 10.1176/appi.neuropsych.14.4.377
M3 - Review article
C2 - 12426407
AN - SCOPUS:0036754864
SN - 0895-0172
VL - 14
SP - 377
EP - 405
JO - Journal of Neuropsychiatry and Clinical Neurosciences
JF - Journal of Neuropsychiatry and Clinical Neurosciences
IS - 4
ER -