Bacteriophage-derived lysins are being developed as anti-infective agents. In an acute osteomyelitis methicillin-resistant Staphylococcus aureus (MRSA) model, rats receiving no treatment or treatment with daptomycin, exebacase (CF-301), or daptomycin plus exebacase had means of 5.13, 4.09, 4.65, and 3.57 log10 CFU/gram of bone, respectively. All treated animals had fewer bacteria than did untreated animals (P≤ 0.0001), with daptomycin plus exebacase being more active than daptomycin (P= 0.0042) or exebacase (P < 0.001) alone.
- Methicillin-resistant Staphylococcus aureus
ASJC Scopus subject areas
- Pharmacology (medical)
- Infectious Diseases