Exclusion of genetic linkage to 4q21-23 and 17q21 in a family with lewy body parkinsonism

John Hardy, Jordi Pérez-Tur, Matt Baker, Matt Farrer, Richard Crook, Mike Hutton, William G. Johnson, Katrina Gwinn, Manfred Muenter, Walter A. Rocca, Demetrius Maraganore

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Genetic analysis of markers from chromosomes 4q21-23 and 17q21 in a family with apparently autosomal dominant Lewy body parkinsonism is presented. This analysis shows that the locus leading to this disease is not allelic with that previously shown to lead to Lewy body parkinsonism on chromosome 4 or to the locus on chromosome 17 leading to frontotemporal dementia with parkinsonism. A brief clinical comparison of this family with families showing linkage to these loci is presented. The data suggest that at least one other major genetic determinant for Lewy body parkinsonism remains to be identified.

Original languageEnglish (US)
Pages (from-to)166-171
Number of pages6
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Volume81
Issue number2
DOIs
StatePublished - Mar 28 1998

Keywords

  • Chromosome 17
  • Chromosome 4
  • Dementia
  • FTDP-17
  • Genetic linkage
  • Parkinson's disease

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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