Exclusion of genetic linkage to 4q21-23 and 17q21 in a family with lewy body parkinsonism

John Hardy; Jordi Pérez-Tur; Matt Baker; Matt Farrer; Richard Crook; Mike Hutton; William G. Johnson; Katrina Gwinn; Manfred Muenter; Walter A. Rocca; Demetrius Maraganore

doi:10.1002/(SICI)1096-8628(19980328)81:2<166::AID-AJMG8>3.0.CO;2-U

Exclusion of genetic linkage to 4q21-23 and 17q21 in a family with lewy body parkinsonism

John Hardy, Jordi Pérez-Tur, Matt Baker, Matt Farrer, Richard Crook, Mike Hutton, William G. Johnson, Katrina Gwinn, Manfred Muenter, Walter A. Rocca, Demetrius Maraganore

Quantitative Health Sciences

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Genetic analysis of markers from chromosomes 4q21-23 and 17q21 in a family with apparently autosomal dominant Lewy body parkinsonism is presented. This analysis shows that the locus leading to this disease is not allelic with that previously shown to lead to Lewy body parkinsonism on chromosome 4 or to the locus on chromosome 17 leading to frontotemporal dementia with parkinsonism. A brief clinical comparison of this family with families showing linkage to these loci is presented. The data suggest that at least one other major genetic determinant for Lewy body parkinsonism remains to be identified.

Original language	English (US)
Pages (from-to)	166-171
Number of pages	6
Journal	American Journal of Medical Genetics - Neuropsychiatric Genetics
Volume	81
Issue number	2
DOIs	https://doi.org/10.1002/(SICI)1096-8628(19980328)81:2<166::AID-AJMG8>3.0.CO;2-U
State	Published - Mar 28 1998

Keywords

Chromosome 17
Chromosome 4
Dementia
FTDP-17
Genetic linkage
Parkinson's disease

ASJC Scopus subject areas

Genetics(clinical)
Psychiatry and Mental health
Cellular and Molecular Neuroscience

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10.1002/(SICI)1096-8628(19980328)81:2<166::AID-AJMG8>3.0.CO;2-U

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Hardy, J., Pérez-Tur, J., Baker, M., Farrer, M., Crook, R., Hutton, M., Johnson, W. G., Gwinn, K., Muenter, M., Rocca, W. A., & Maraganore, D. (1998). Exclusion of genetic linkage to 4q21-23 and 17q21 in a family with lewy body parkinsonism. American Journal of Medical Genetics - Neuropsychiatric Genetics, 81(2), 166-171. https://doi.org/10.1002/(SICI)1096-8628(19980328)81:2<166::AID-AJMG8>3.0.CO;2-U

Hardy, J, Pérez-Tur, J, Baker, M, Farrer, M, Crook, R, Hutton, M, Johnson, WG, Gwinn, K, Muenter, M, Rocca, WA & Maraganore, D 1998, 'Exclusion of genetic linkage to 4q21-23 and 17q21 in a family with lewy body parkinsonism', American Journal of Medical Genetics - Neuropsychiatric Genetics, vol. 81, no. 2, pp. 166-171. https://doi.org/10.1002/(SICI)1096-8628(19980328)81:2<166::AID-AJMG8>3.0.CO;2-U

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abstract = "Genetic analysis of markers from chromosomes 4q21-23 and 17q21 in a family with apparently autosomal dominant Lewy body parkinsonism is presented. This analysis shows that the locus leading to this disease is not allelic with that previously shown to lead to Lewy body parkinsonism on chromosome 4 or to the locus on chromosome 17 leading to frontotemporal dementia with parkinsonism. A brief clinical comparison of this family with families showing linkage to these loci is presented. The data suggest that at least one other major genetic determinant for Lewy body parkinsonism remains to be identified.",

keywords = "Chromosome 17, Chromosome 4, Dementia, FTDP-17, Genetic linkage, Parkinson's disease",

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AU - Hardy, John

AU - Pérez-Tur, Jordi

AU - Baker, Matt

AU - Farrer, Matt

AU - Crook, Richard

AU - Hutton, Mike

AU - Johnson, William G.

AU - Gwinn, Katrina

AU - Muenter, Manfred

AU - Rocca, Walter A.

AU - Maraganore, Demetrius

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N2 - Genetic analysis of markers from chromosomes 4q21-23 and 17q21 in a family with apparently autosomal dominant Lewy body parkinsonism is presented. This analysis shows that the locus leading to this disease is not allelic with that previously shown to lead to Lewy body parkinsonism on chromosome 4 or to the locus on chromosome 17 leading to frontotemporal dementia with parkinsonism. A brief clinical comparison of this family with families showing linkage to these loci is presented. The data suggest that at least one other major genetic determinant for Lewy body parkinsonism remains to be identified.

AB - Genetic analysis of markers from chromosomes 4q21-23 and 17q21 in a family with apparently autosomal dominant Lewy body parkinsonism is presented. This analysis shows that the locus leading to this disease is not allelic with that previously shown to lead to Lewy body parkinsonism on chromosome 4 or to the locus on chromosome 17 leading to frontotemporal dementia with parkinsonism. A brief clinical comparison of this family with families showing linkage to these loci is presented. The data suggest that at least one other major genetic determinant for Lewy body parkinsonism remains to be identified.

KW - Chromosome 17

KW - Chromosome 4

KW - Dementia

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KW - Genetic linkage

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Exclusion of genetic linkage to 4q21-23 and 17q21 in a family with lewy body parkinsonism

Abstract

Keywords

ASJC Scopus subject areas

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