Abstract
To generate transcriptionally targeted vectors, tissue-specific elements of the human tyrosinase promoter were exchanged with corresponding viral elements in the Moloney murine leukemia virus long terminal repeat (LTR). From these experiments, a vesicular stomatitis virus type G pseudotyped, hybrid LTR vector that contained three tyrosinase enhancer elements and gave high-level, tightly tissue-specific expression at high titers (3 x 107 CFU/ml) was constructed.
Original language | English (US) |
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Pages (from-to) | 789-795 |
Number of pages | 7 |
Journal | Journal of virology |
Volume | 72 |
Issue number | 1 |
DOIs | |
State | Published - Jan 1998 |
ASJC Scopus subject areas
- Microbiology
- Immunology
- Insect Science
- Virology