To generate transcriptionally targeted vectors, tissue-specific elements of the human tyrosinase promoter were exchanged with corresponding viral elements in the Moloney murine leukemia virus long terminal repeat (LTR). From these experiments, a vesicular stomatitis virus type G pseudotyped, hybrid LTR vector that contained three tyrosinase enhancer elements and gave high-level, tightly tissue-specific expression at high titers (3 x 107 CFU/ml) was constructed.
|Original language||English (US)|
|Number of pages||7|
|Journal||Journal of virology|
|State||Published - Jan 1 1998|
ASJC Scopus subject areas
- Insect Science